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INSRR insulin receptor related receptor [ Canis lupus familiaris (dog) ]

Gene ID: 490405, updated on 5-Mar-2024

Summary

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Official Symbol
INSRRprovided by VGNC
Official Full Name
insulin receptor related receptorprovided by VGNC
Primary source
VGNC:VGNC:42044
See related
Ensembl:ENSCAFG00845007933
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (41023495..41039193)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (40648067..40663757)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (41142065..41157749)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (40805532..40821218)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (40858559..40874251)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene uncharacterized LOC111096728 Neighboring gene SH2 domain containing 2A Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene proline rich mitotic checkpoint control factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor-related protein
XP_005622745.1
XP_022276946.1
XP_022276947.1
XP_038337533.1
XP_038337534.1
XP_038337535.1
XP_038398902.1
XP_038398904.1
XP_038398905.1
XP_038463016.1
XP_038463017.1
XP_038463018.1
XP_038463019.1
XP_038527741.1
XP_038527742.1
XP_038527743.1
XP_038527744.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    41023495..41039193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038671815.1 → XP_038527743.1  insulin receptor-related protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0JX12
    Conserved Domains (4) summary
    cd05032
    Location:972 → 1221
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:819 → 909
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:174 → 326
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346 → 460
    Recep_L_domain; Receptor L domain

  2. XM_038671813.1 → XP_038527741.1  insulin receptor-related protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0JX12
    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1261
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain

  3. XM_038671814.1 → XP_038527742.1  insulin receptor-related protein isoform X2

    UniProtKB/TrEMBL
    A0A8C0M576, A0A8C0T4K5, A0A8P0SKW6
    Related
    ENSCAFP00845010827.1, ENSCAFT00845013970.1
    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1286
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain

  4. XM_038671816.1 → XP_038527744.1  insulin receptor-related protein isoform X4

    Conserved Domains (4) summary
    cd05032
    Location:812 → 1061
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    PRK12323
    Location:85 → 201
    PRK12323; DNA polymerase III subunit gamma/tau
    cd00063
    Location:659 → 749
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam01030
    Location:203 → 300
    Recep_L_domain; Receptor L domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    40805532..40821218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038481607.1 → XP_038337535.1  insulin receptor-related protein isoform X3

    Conserved Domains (4) summary
    cd05032
    Location:972 → 1221
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:819 → 909
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:174 → 326
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346 → 460
    Recep_L_domain; Receptor L domain

  2. XM_038481605.1 → XP_038337533.1  insulin receptor-related protein isoform X1

    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1261
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain

  3. XM_038481606.1 → XP_038337534.1  insulin receptor-related protein isoform X2

    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1286
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    40858559..40874251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038607090.1 → XP_038463018.1  insulin receptor-related protein isoform X3

    Conserved Domains (4) summary
    cd05032
    Location:972 → 1221
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:819 → 909
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:174 → 326
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346 → 460
    Recep_L_domain; Receptor L domain

  2. XM_038607088.1 → XP_038463016.1  insulin receptor-related protein isoform X1

    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1261
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain

  3. XM_038607089.1 → XP_038463017.1  insulin receptor-related protein isoform X2

    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1286
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain

  4. XM_038607091.1 → XP_038463019.1  insulin receptor-related protein isoform X4

    Conserved Domains (4) summary
    cd05032
    Location:812 → 1061
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    PRK12323
    Location:85 → 201
    PRK12323; DNA polymerase III subunit gamma/tau
    cd00063
    Location:659 → 749
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam01030
    Location:203 → 300
    Recep_L_domain; Receptor L domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    41142065..41157749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038542977.1 → XP_038398905.1  insulin receptor-related protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0JX12
    Conserved Domains (4) summary
    cd05032
    Location:972 → 1221
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:819 → 909
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:174 → 326
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346 → 460
    Recep_L_domain; Receptor L domain

  2. XM_038542974.1 → XP_038398902.1  insulin receptor-related protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0JX12
    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1261
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain

  3. XM_038542976.1 → XP_038398904.1  insulin receptor-related protein isoform X2

    UniProtKB/TrEMBL
    A0A8C0M576, A0A8C0T4K5, A0A8P0SKW6
    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1286
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    40648067..40663757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005622688.3 → XP_005622745.1  insulin receptor-related protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0JX12
    Conserved Domains (4) summary
    cd05032
    Location:972 → 1221
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:819 → 909
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:174 → 326
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346 → 460
    Recep_L_domain; Receptor L domain

  2. XM_022421238.2 → XP_022276946.1  insulin receptor-related protein isoform X1

    UniProtKB/TrEMBL
    A0A8C0JX12
    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1261
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain

  3. XM_022421239.2 → XP_022276947.1  insulin receptor-related protein isoform X2

    UniProtKB/TrEMBL
    A0A8C0M576, A0A8C0T4K5, A0A8P0SKW6
    Conserved Domains (4) summary
    cd05032
    Location:1012 → 1286
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:859 → 949
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:214 → 366
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:386 → 500
    Recep_L_domain; Receptor L domain
Nucleotide Protein
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