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LRRC8C leucine rich repeat containing 8 VRAC subunit C [ Canis lupus familiaris (dog) ]

Gene ID: 490168, updated on 5-Mar-2024

Summary

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Official Symbol
LRRC8Cprovided by VGNC
Official Full Name
leucine rich repeat containing 8 VRAC subunit Cprovided by VGNC
Primary source
VGNC:VGNC:42816
See related
Ensembl:ENSCAFG00845017546
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (59407523..59492055, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (61605421..61690225, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (59414770..59499275, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (58981235..59065445, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (58934585..59019172, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene 39S ribosomal protein L30, mitochondrial-like Neighboring gene uncharacterized LOC111096522 Neighboring gene uncharacterized LOC111096524 Neighboring gene palmitoyltransferase ZDHHC6-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
volume-regulated anion channel subunit LRRC8C
Names
leucine rich repeat containing 8 family member C

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    59407523..59492055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038670192.1 → XP_038526120.1  volume-regulated anion channel subunit LRRC8C isoform X1

    UniProtKB/TrEMBL
    A0A8C0KHW2, A0A8C0NUD7, A0A8I3RZY3, A0A8I3S2P8
    Related
    ENSCAFP00845024369.1, ENSCAFT00845031114.1
    Conserved Domains (4) summary
    COG4886
    Location:528 → 775
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:446 → 468
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:469 → 492
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 338
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_038670193.1 → XP_038526121.1  volume-regulated anion channel subunit LRRC8C isoform X2

    UniProtKB/TrEMBL
    A0A8I3RZY3
    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_038670194.1 → XP_038526122.1  volume-regulated anion channel subunit LRRC8C isoform X2

    UniProtKB/TrEMBL
    A0A8I3RZY3
    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    58981235..59065445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038480121.1 → XP_038336049.1  volume-regulated anion channel subunit LRRC8C isoform X1

    Conserved Domains (4) summary
    COG4886
    Location:528 → 775
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:446 → 468
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:469 → 492
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 338
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_038480122.1 → XP_038336050.1  volume-regulated anion channel subunit LRRC8C isoform X2

    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_038480123.1 → XP_038336051.1  volume-regulated anion channel subunit LRRC8C isoform X2

    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    58934585..59019172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038605575.1 → XP_038461503.1  volume-regulated anion channel subunit LRRC8C isoform X1

    Conserved Domains (4) summary
    COG4886
    Location:528 → 775
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:446 → 468
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:469 → 492
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 338
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_038605576.1 → XP_038461504.1  volume-regulated anion channel subunit LRRC8C isoform X2

    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_038605577.1 → XP_038461505.1  volume-regulated anion channel subunit LRRC8C isoform X2

    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    59414770..59499275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038541439.1 → XP_038397367.1  volume-regulated anion channel subunit LRRC8C isoform X1

    UniProtKB/TrEMBL
    A0A8C0KHW2, A0A8C0NUD7, A0A8I3RZY3, A0A8I3S2P8
    Conserved Domains (4) summary
    COG4886
    Location:528 → 775
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:446 → 468
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:469 → 492
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 338
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_038541440.1 → XP_038397368.1  volume-regulated anion channel subunit LRRC8C isoform X2

    UniProtKB/TrEMBL
    A0A8I3RZY3
    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_038541442.1 → XP_038397370.1  volume-regulated anion channel subunit LRRC8C isoform X2

    UniProtKB/TrEMBL
    A0A8I3RZY3
    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    61605421..61690225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038555608.1 → XP_038411536.1  volume-regulated anion channel subunit LRRC8C isoform X1

    UniProtKB/TrEMBL
    A0A8P0SP38, A0A8P0TUV9
    Conserved Domains (4) summary
    COG4886
    Location:528 → 775
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:446 → 468
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:469 → 492
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 338
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_005621951.4 → XP_005622008.1  volume-regulated anion channel subunit LRRC8C isoform X2

    See identical proteins and their annotated locations for XP_005622008.1

    UniProtKB/TrEMBL
    A0A8P0TUV9
    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_038555627.1 → XP_038411555.1  volume-regulated anion channel subunit LRRC8C isoform X2

    UniProtKB/TrEMBL
    A0A8P0TUV9
    Conserved Domains (4) summary
    COG4886
    Location:481 → 728
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:399 → 421
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:422 → 445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 291
    Pannexin_like; Pannexin-like TM region of LRRC8
Nucleotide Protein
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