ITGAD integrin subunit alpha D [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: ITGAD
Gene description: integrin subunit alpha D
See related: Ensembl:ENSCAFG00845010970
Gene type: protein coding
RefSeq status: INFERRED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: CD11d
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Genomic context

Location:: chromosome: 6

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	6	NC_051810.1 (16930226..16958790, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	6	NC_006588.4 (18354250..18357206)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	6	NC_049227.1 (16968289..16993053, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	6	NC_049266.1 (16737256..16761995, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	6	NC_049747.1 (16656592..16681338, complement)

Chromosome 6 - NC_051810.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression of CD11d in splenic and bone marrow macrophages in dogs with hemophagocytic histiocytic sarcoma is reported.
Title: Canine hemophagocytic histiocytic sarcoma: a proliferative disorder of CD11d+ macrophages.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: integrin alpha-D

Names: integrin, alpha D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110802.2 → NP_001104272.2 integrin alpha-D

Status: INFERRED

Source sequence(s)

JAAUVH010000065

UniProtKB/TrEMBL

A0A8C0RC29, A0A8C0S784, A0A8I3NHS5

Related

ENSCAFP00845015561.1, ENSCAFT00845019867.1

Conserved Domains (4) summary

smart00191
Location:524 → 579

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:157 → 332

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1131 → 1145

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:622 → 964

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051810.1 Reference ROS_Cfam_1.0

Range

16930226..16958790 complement

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mRNA and Protein(s)

XM_038667605.1 → XP_038523533.1 integrin alpha-D isoform X3

UniProtKB/TrEMBL

A0A8C0L7I0

Conserved Domains (3) summary

smart00191
Location:553 → 608

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:154 → 361

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:651 → 993

Integrin_alpha2; Integrin alpha
XM_038667604.1 → XP_038523532.1 integrin alpha-D isoform X2

UniProtKB/TrEMBL

A0A8C0L7I0

Conserved Domains (4) summary

smart00191
Location:539 → 594

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam00357
Location:1146 → 1160

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:637 → 979

Integrin_alpha2; Integrin alpha

cl00057
Location:154 → 347

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_038667606.1 → XP_038523534.1 integrin alpha-D isoform X4

UniProtKB/TrEMBL

A0A8C0L7I0

Conserved Domains (4) summary

smart00191
Location:521 → 576

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:154 → 329

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1128 → 1142

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:619 → 961

Integrin_alpha2; Integrin alpha
XM_038667603.1 → XP_038523531.1 integrin alpha-D isoform X1

UniProtKB/TrEMBL

A0A8C0L7I0

Conserved Domains (4) summary

smart00191
Location:553 → 608

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:154 → 361

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam00357
Location:1160 → 1174

Integrin_alpha; Integrin alpha cytoplasmic region

pfam08441
Location:651 → 993

Integrin_alpha2; Integrin alpha

Alternate UMICH_Zoey_3.1

Genomic

NC_049266.1 Alternate UMICH_Zoey_3.1

Range

16737256..16761995 complement

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Alternate UNSW_CanFamBas_1.0

Genomic

NC_049747.1 Alternate UNSW_CanFamBas_1.0

Range

16656592..16681338 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049227.1 Alternate UU_Cfam_GSD_1.0

Range

16968289..16993053 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

18354250..18357206

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038558416.1 → XP_038414344.1 integrin alpha-D isoform X5

Conserved Domains (1) summary

pfam00357
Location:226 → 240

Integrin_alpha; Integrin alpha cytoplasmic region