PARD6A par-6 family cell polarity regulator alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PARD6Aprovided by VGNC
Official Full Name: par-6 family cell polarity regulator alphaprovided by VGNC
Primary source: VGNC:VGNC:44265
See related: Ensembl:ENSCAFG00845006886
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	5	NC_051809.1 (82222592..82224980, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	5	NC_006587.4 (81777186..81779574, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	5	NC_049226.1 (82373005..82375393, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	5	NC_049265.1 (82048921..82051309, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	5	NC_049746.1 (81730456..81732843, complement)

Chromosome 5 - NC_051809.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in centrosome cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in establishment or maintenance of cell polarity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cellular localization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: partitioning defective 6 homolog alpha

Names: par-6 partitioning defective 6 homolog alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051809.1 Reference ROS_Cfam_1.0

Range

82222592..82224980 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038667322.1 → XP_038523250.1 partitioning defective 6 homolog alpha isoform X1

UniProtKB/TrEMBL

A0A8I3RTL4, A0A8P0SU80

Related

ENSCAFP00845009554.1, ENSCAFT00845012222.1

Conserved Domains (2) summary

cd06403
Location:184 → 263

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:324 → 415

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038667323.1 → XP_038523251.1 partitioning defective 6 homolog alpha isoform X2

UniProtKB/TrEMBL

A0A8C0YZ65

Conserved Domains (2) summary

cd06403
Location:16 → 95

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:155 → 246

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038667324.1 → XP_038523252.1 partitioning defective 6 homolog alpha isoform X3

UniProtKB/TrEMBL

A0A8C0YZ65

Conserved Domains (2) summary

cd06403
Location:18 → 91

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:152 → 243

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049265.1 Alternate UMICH_Zoey_3.1

Range

82048921..82051309 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038477391.1 → XP_038333319.1 partitioning defective 6 homolog alpha isoform X1

Conserved Domains (2) summary

cd06403
Location:184 → 263

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:324 → 415

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038477392.1 → XP_038333320.1 partitioning defective 6 homolog alpha isoform X2

Conserved Domains (2) summary

cd06403
Location:16 → 95

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:155 → 246

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038477393.1 → XP_038333321.1 partitioning defective 6 homolog alpha isoform X3

Conserved Domains (2) summary

cd06403
Location:18 → 91

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:152 → 243

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049746.1 Alternate UNSW_CanFamBas_1.0

Range

81730456..81732843 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038602713.1 → XP_038458641.1 partitioning defective 6 homolog alpha isoform X1

Conserved Domains (2) summary

cd06403
Location:184 → 263

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:324 → 415

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038602714.1 → XP_038458642.1 partitioning defective 6 homolog alpha isoform X2

Conserved Domains (2) summary

cd06403
Location:16 → 95

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:155 → 246

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038602715.1 → XP_038458643.1 partitioning defective 6 homolog alpha isoform X3

Conserved Domains (2) summary

cd06403
Location:18 → 91

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:152 → 243

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049226.1 Alternate UU_Cfam_GSD_1.0

Range

82373005..82375393 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038538598.1 → XP_038394526.1 partitioning defective 6 homolog alpha isoform X1

UniProtKB/TrEMBL

A0A8I3RTL4, A0A8P0SU80

Conserved Domains (2) summary

cd06403
Location:184 → 263

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:324 → 415

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038538599.1 → XP_038394527.1 partitioning defective 6 homolog alpha isoform X2

UniProtKB/TrEMBL

A0A8C0YZ65

Conserved Domains (2) summary

cd06403
Location:16 → 95

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:155 → 246

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_038538600.1 → XP_038394528.1 partitioning defective 6 homolog alpha isoform X3

UniProtKB/TrEMBL

A0A8C0YZ65

Conserved Domains (2) summary

cd06403
Location:18 → 91

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:152 → 243

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

81777186..81779574 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_546876.7 → XP_546876.5 partitioning defective 6 homolog alpha isoform X1

UniProtKB/TrEMBL

A0A8I3RTL4, A0A8P0SU80

Conserved Domains (2) summary

cd06403
Location:184 → 263

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:324 → 415

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_005620817.3 → XP_005620874.2 partitioning defective 6 homolog alpha isoform X2

UniProtKB/TrEMBL

A0A8C0YZ65

Conserved Domains (2) summary

cd06403
Location:16 → 95

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:155 → 246

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_022419316.2 → XP_022275024.2 partitioning defective 6 homolog alpha isoform X3

UniProtKB/TrEMBL

A0A8C0YZ65

Conserved Domains (2) summary

cd06403
Location:18 → 91

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:152 → 243

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...