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CASP9 caspase 9 [ Canis lupus familiaris (dog) ]

Gene ID: 487432, updated on 5-Mar-2024

Summary

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Official Symbol
CASP9provided by VGNC
Official Full Name
caspase 9provided by VGNC
Primary source
VGNC:VGNC:58438
See related
Ensembl:ENSCAFG00845000379
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
ICE-LAP6
Orthologs
human mouse all
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Genomic context

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See CASP9 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (82683018..82723170)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (78571149..78590692)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (81519391..81539023)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (79435738..79455337)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (80453740..80473245)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene agmatinase (putative) Neighboring gene uncharacterized LOC119870485 Neighboring gene DnaJ heat shock protein family (Hsp40) member C16 Neighboring gene chymotrypsin-C Neighboring gene EF-hand domain family member D2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus. Del Puerto HL, et al. Genet Mol Res, 2010 Jan 26. PMID 20198571

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
caspase-9
Names
caspase 9, apoptosis-related cysteine protease
NP_001026803.1
XP_038513758.1
XP_038513759.1
XP_038513760.1
XP_038513761.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031633.1 → NP_001026803.1  caspase-9

    See identical proteins and their annotated locations for NP_001026803.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ116956
    UniProtKB/TrEMBL
    A0A8C0Q619, A0A8I3MCG3, A0A8P0NV46, Q45T68
    Related
    ENSCAFP00845000450.1, ENSCAFT00845000639.1
    Conserved Domains (2) summary
    cd00032
    Location:182 → 444
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:19 → 90
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    82683018..82723170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657833.1 → XP_038513761.1  caspase-9 isoform X4

    Conserved Domains (1) summary
    cd00032
    Location:10 → 244
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_038657830.1 → XP_038513758.1  caspase-9 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PZQ5
    Conserved Domains (2) summary
    cd00032
    Location:182 → 416
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:19 → 90
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_038657831.1 → XP_038513759.1  caspase-9 isoform X2

    UniProtKB/TrEMBL
    A0A8C0PZQ5
    Conserved Domains (2) summary
    cd00032
    Location:182 → 416
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:19 → 90
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_038657832.1 → XP_038513760.1  caspase-9 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MV67, A0A8P0SRU9
    Conserved Domains (2) summary
    cd00032
    Location:182 → 417
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:19 → 90
    DD; Death Domain Superfamily of protein-protein interaction domains

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    79435738..79455337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    80453740..80473245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    81519391..81539023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    78571149..78590692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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