Hrb87F Heterogeneous nuclear ribonucleoprotein at 87F [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hrb87Fprovided by FlyBase
Official Full Name: Heterogeneous nuclear ribonucleoprotein at 87Fprovided by FlyBase
Primary source: FLYBASE:FBgn0004237
Locus tag: Dmel_CG12749
See related: AllianceGenome:FB:FBgn0004237
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12749; Dmel\CG12749; hnRNP A2/B1; hnRNP36; hnRNPA1; hnRNPA1/A2; hnRNPA2; hnRNPA2/B1; Hrb2; Hrb85CD; hrb87f; Hrb87f; HRB87F; HRB87F/hrp36; Hrb87Fa; hrp36; Hrp36; HRP36; P11; P11/Hrb87F; p38; Q14; Q16
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including animal organ development; regulation of alternative mRNA splicing, via spliceosome; and response to heat. Located in heterochromatin; omega speckle; and polytene chromosome puff. Part of ribonucleoprotein complex. Is expressed in adult head; adult heart; larval midline neurons; and ovary. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with Paget disease of bone and frontotemporal dementia; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 87F7-87F7; 3-54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13656846..13660531, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9482568..9486253, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The hnRNP A1 homolog Hrb87F/Hrp36 is important for telomere maintenance in Drosophila melanogaster.
Title: The hnRNP A1 homolog Hrb87F/Hrp36 is important for telomere maintenance in Drosophila melanogaster.
Hrp36 is essential for normal development and for survival under conditions of stress
Title: The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster.
shows that the heterogeneous nuclear ribonucleoprotein hrp36 acts specifically within, and throughout, the exon 6 cluster to prevent the inclusion of multiple exons.
Title: A regulator of Dscam mutually exclusive splicing fidelity.
direct and indirect interactions of the hsromega transcripts with a variety of regulatory proteins like hnRNPs, CBP, proteasome, Drosophila inhibitor of apoptosis protein 1 (DIAP1)
Title: Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(G) binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in positive regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in omega speckle	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein at 87F

Names: CG12749-PA; CG12749-PC; CG12749-PD; CG12749-PE; Hrb87F-PA; Hrb87F-PC; Hrb87F-PD; Hrb87F-PE; heterogeneous nuclear ribonucleoprotein at 85CD; hnRNA-binding protein 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

13656846..13660531 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275609.1 → NP_001262538.1 heterogeneous nuclear ribonucleoprotein at 87F, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262538.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48810, Q24486, Q8INH0, Q9VFT2

UniProtKB/TrEMBL

E1JIK0

Conserved Domains (2) summary

cd12578
Location:25 → 102

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:116 → 188

RRM_SF; RNA recognition motif (RRM) superfamily
NM_057458.5 → NP_476806.2 heterogeneous nuclear ribonucleoprotein at 87F, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476806.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P48810, Q24486, Q8INH0, Q9VFT2

UniProtKB/TrEMBL

E1JIK0

Conserved Domains (2) summary

cd12578
Location:25 → 102

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:116 → 188

RRM_SF; RNA recognition motif (RRM) superfamily
NM_057459.5 → NP_476807.1 heterogeneous nuclear ribonucleoprotein at 87F, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476807.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48810, Q24486, Q8INH0, Q9VFT2

UniProtKB/TrEMBL

E1JIK0

Related

FBpp0082316

Conserved Domains (2) summary

cd12578
Location:25 → 102

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:116 → 188

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001170131.2 → NP_001163602.1 heterogeneous nuclear ribonucleoprotein at 87F, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163602.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48810, Q24486, Q8INH0, Q9VFT2

UniProtKB/TrEMBL

E1JIK0

Conserved Domains (2) summary

cd12578
Location:25 → 102

RRM1_hnRNPA_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A subfamily

cl17169
Location:116 → 188

RRM_SF; RNA recognition motif (RRM) superfamily