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MAN2B1 mannosidase alpha class 2B member 1 [ Canis lupus familiaris (dog) ]

Gene ID: 484932, updated on 5-Mar-2024

Summary

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Official Symbol
MAN2B1provided by VGNC
Official Full Name
mannosidase alpha class 2B member 1provided by VGNC
Primary source
VGNC:VGNC:108249
See related
Ensembl:ENSCAFG00845017174
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See MAN2B1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (49964867..49980270)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (49319770..49335161)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (49844716..49860091)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (49175662..49191234)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (49602404..49618026)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 14 Neighboring gene deoxyhypusine synthase Neighboring gene WD repeat domain 83 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene uncharacterized LOC119864736 Neighboring gene zinc finger protein 791 Neighboring gene zinc finger protein 709-like Neighboring gene uncharacterized LOC106560136

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Homozygous MAN2B1 Missense Mutation in a Doberman Pinscher Dog with Neurodegeneration, Cytoplasmic Vacuoles, Autofluorescent Storage Granules, and an alpha-Mannosidase Deficiency.
    Title: A Homozygous MAN2B1 Missense Mutation in a Doberman Pinscher Dog with Neurodegeneration, Cytoplasmic Vacuoles, Autofluorescent Storage Granules, and an α-Mannosidase Deficiency.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lysosomal alpha-mannosidase
XP_005632890.1
XP_038284422.1
XP_038284423.1
XP_038360064.1
XP_038360065.1
XP_038423093.1
XP_038423094.1
XP_038487236.1
XP_038487237.1
XP_542048.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    49964867..49980270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038428494.1 → XP_038284422.1  lysosomal alpha-mannosidase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NTM5
    Conserved Domains (2) summary
    PLN02701
    Location:65 → 998
    PLN02701; alpha-mannosidase
    cd10810
    Location:65 → 343
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)

  2. XM_038428495.1 → XP_038284423.1  lysosomal alpha-mannosidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3NTM5
    Related
    ENSCAFP00845024281.1, ENSCAFT00845030987.1
    Conserved Domains (2) summary
    PLN02701
    Location:65 → 997
    PLN02701; alpha-mannosidase
    cd10810
    Location:65 → 343
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    49175662..49191234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038504136.1 → XP_038360064.1  lysosomal alpha-mannosidase isoform X1

  2. XM_038504137.1 → XP_038360065.1  lysosomal alpha-mannosidase isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    49602404..49618026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038631308.1 → XP_038487236.1  lysosomal alpha-mannosidase isoform X1

  2. XM_038631309.1 → XP_038487237.1  lysosomal alpha-mannosidase isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    49844716..49860091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038567165.1 → XP_038423093.1  lysosomal alpha-mannosidase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NTM5

  2. XM_038567166.1 → XP_038423094.1  lysosomal alpha-mannosidase isoform X2

    UniProtKB/TrEMBL
    A0A8C0TQU3, A0A8I3NTM5

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    49319770..49335161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005632833.4 → XP_005632890.1  lysosomal alpha-mannosidase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NTM5
    Conserved Domains (4) summary
    PLN02701
    Location:65 → 998
    PLN02701; alpha-mannosidase
    cd10810
    Location:65 → 343
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:390 → 468
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:513 → 998
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

  2. XM_542048.5 → XP_542048.3  lysosomal alpha-mannosidase isoform X2

    UniProtKB/TrEMBL
    A0A8C0TQU3, A0A8I3NTM5
    Conserved Domains (4) summary
    PLN02701
    Location:65 → 997
    PLN02701; alpha-mannosidase
    cd10810
    Location:65 → 343
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:389 → 467
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:512 → 997
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
Nucleotide Protein
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