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CTSO cathepsin O [ Canis lupus familiaris (dog) ]

Gene ID: 482665, updated on 17-Aug-2024

Summary

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Official Symbol
CTSOprovided by VGNC
Official Full Name
cathepsin Oprovided by VGNC
Primary source
VGNC:VGNC:54198
See related
Ensembl:ENSCAFG00845010853
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
8
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (54134250..54157750, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (53762705..53786762, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (53811032..53834587, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (53387542..53411063, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (53496778..53520309, complement)

Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene acid sensing ion channel subunit family member 5 Neighboring gene tryptophan 2,3-dioxygenase Neighboring gene uncharacterized LOC111090110 Neighboring gene casein kinase I-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cathepsin O
XP_005629509.2
XP_038352625.1
XP_038415111.1
XP_038478958.1
XP_038544630.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051819.1 Reference ROS_Cfam_1.0

    Range
    54134250..54157750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038688702.1 → XP_038544630.1  cathepsin O isoform X1

    UniProtKB/TrEMBL
    A0A8C0SLA3, A0A8I3NHB2
    Related
    ENSCAFP00845014970.1, ENSCAFT00845019160.1
    Conserved Domains (2) summary
    cd02248
    Location:108 → 318
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
    cl22448
    Location:41 → 79
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049275.1 Alternate UMICH_Zoey_3.1

    Range
    53387542..53411063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038496697.1 → XP_038352625.1  cathepsin O isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

    Range
    53496778..53520309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038623030.1 → XP_038478958.1  cathepsin O isoform X1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

    Range
    53811032..53834587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038559183.1 → XP_038415111.1  cathepsin O isoform X2

    UniProtKB/TrEMBL
    A0A8C0JNS2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    53762705..53786762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005629452.2 → XP_005629509.2  cathepsin O isoform X1

    UniProtKB/TrEMBL
    A0A8C0SLA3, A0A8P0SDM5
    Conserved Domains (2) summary
    cd02248
    Location:108 → 318
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
    cl22448
    Location:41 → 79
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
Nucleotide Protein
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