TMPRSS2 transmembrane serine protease 2 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: TMPRSS2provided by VGNC
Official Full Name: transmembrane serine protease 2provided by VGNC
Primary source: VGNC:VGNC:3729
Locus tag: CK820_G0022846
See related: Ensembl:ENSPTRG00000013928
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	22	NC_072420.2 (42140520..42184235, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	21	NC_072419.1 (39790994..39836989, complement)

Chromosome 22 - NC_072420.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

PMC310729P10 (e-PCR)
- UniSTS:272650

D21S1876 (e-PCR)
- UniSTS:18966

SHGC-147650 (e-PCR)
- UniSTS:175933

G29032 (e-PCR)
- UniSTS:24652

TMPRSS2_7892 (e-PCR)
- UniSTS:466515

SHGC-87658 (e-PCR)
- UniSTS:62077

G62824 (e-PCR)
- UniSTS:139949

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: transmembrane protease serine 2

Names: transmembrane protease, serine 2

XP_001172064.5

EC 3.4.21.-

EC 3.4.21.122

XP_016794054.1

EC 3.4.21.-

EC 3.4.21.122

XP_016794055.1

EC 3.4.21.-

EC 3.4.21.122

XP_054531095.1

EC 3.4.21.-

EC 3.4.21.122

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072420.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

42140520..42184235 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016938565.4 → XP_016794054.1 transmembrane protease serine 2 isoform X1

UniProtKB/TrEMBL

A0A2J8M861, A0A6D2WBC5, H2QL19, Q3I1V5

Conserved Domains (3) summary

cd00112
Location:113 → 148

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:256 → 487

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam15494
Location:153 → 246

SRCR_2; Scavenger receptor cysteine-rich domain
XM_054675120.2 → XP_054531095.1 transmembrane protease serine 2 isoform X3

UniProtKB/TrEMBL

Q3I1V5
XM_016938566.4 → XP_016794055.1 transmembrane protease serine 2 isoform X2

UniProtKB/TrEMBL

Q3I1V5
XM_001172064.7 → XP_001172064.5 transmembrane protease serine 2 isoform X1

UniProtKB/TrEMBL

A0A2J8M861, A0A6D2WBC5, H2QL19, Q3I1V5