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TPH2 tryptophan hydroxylase 2 [ Pan troglodytes (chimpanzee) ]

Gene ID: 467070, updated on 17-Aug-2024

Summary

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Official Symbol
TPH2provided by VGNC
Official Full Name
tryptophan hydroxylase 2provided by VGNC
Primary source
VGNC:VGNC:8582
Locus tag
CK820_G0020369
See related
Ensembl:ENSPTRG00000044968
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 10 NC_072408.2 (78688825..78785027)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 12 NC_072410.1 (77292702..77401007)

Chromosome 10 - NC_072408.2Genomic Context describing neighboring genes Neighboring gene RAB21, member RAS oncogene family Neighboring gene magnesium transporter MRS2 homolog, mitochondrial-like Neighboring gene TBC1 domain family member 15 Neighboring gene uncharacterized LOC129136657 Neighboring gene thyrotropin releasing hormone degrading enzyme

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polymorphism of the tryptophan hydroxylase 2 (TPH2) gene is associated with chimpanzee neuroticism. Hong KW, et al. PLoS One, 2011. PMID 21765945, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of TPH2 SNP with neuroticism in captive and wild-born chimpanzees living in Japan and Guinea, respectively, was tested.
    Title: Polymorphism of the tryptophan hydroxylase 2 (TPH2) gene is associated with chimpanzee neuroticism.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tryptophan 5-hydroxylase 2
Names
neuronal tryptophan hydroxylase
XP_522470.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    78688825..78785027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_522470.7 → XP_522470.2  tryptophan 5-hydroxylase 2

    See identical proteins and their annotated locations for XP_522470.2

    UniProtKB/TrEMBL
    A0A2I3TG35, A0A2J8MJ72, A0A6D2W9R0
    Related
    ENSPTRP00000088217.1
    Conserved Domains (2) summary
    pfam00351
    Location:152 → 482
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    cl09141
    Location:64 → 137
    ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials