DLC1 DLC1 Rho GTPase activating protein [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: DLC1provided by VGNC
Official Full Name: DLC1 Rho GTPase activating proteinprovided by VGNC
Primary source: VGNC:VGNC:13167
Locus tag: CK820_G0041535
See related: Ensembl:ENSPTRG00000020009
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	7	NC_072405.2 (21339822..21867217, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	8	NC_072406.1 (24928290..25456351, complement)

Chromosome 7 - NC_072405.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH12354 (e-PCR)
- UniSTS:78592

D8S1754 (e-PCR), detects polymorphism
- UniSTS:26626

DLC1__4743 (e-PCR)
- UniSTS:462870

STS-N74419 (e-PCR)
- UniSTS:69668

D8S1636 (e-PCR)
- UniSTS:22311

RH69264 (e-PCR)
- UniSTS:53297

D8S13124 (e-PCR)
- UniSTS:265018

D8S13129 (e-PCR)
- UniSTS:265019

D8S13141 (e-PCR)
- UniSTS:265020

RH123765 (e-PCR)
- UniSTS:137789

RH92548 (e-PCR)
- UniSTS:91720

SHGC-31942 (e-PCR)
- UniSTS:15689

SHGC-142756 (e-PCR)
- UniSTS:171636

D8S1690 (e-PCR)
- UniSTS:154267

G19789 (e-PCR)
- UniSTS:32670

A001Y28 (e-PCR)
- UniSTS:32671

D8S1182 (e-PCR)
- UniSTS:150192

G59317 (e-PCR)
- UniSTS:136632

SHGC-80952 (e-PCR)
- UniSTS:102585

WI-18560 (e-PCR)
- UniSTS:16060

G63522 (e-PCR)
- UniSTS:140484

WIAF-1709 (e-PCR)
- UniSTS:24782

SHGC-83879 (e-PCR)
- UniSTS:101847

WI-22147 (e-PCR)
- UniSTS:25569

D8S1513 (e-PCR)
- UniSTS:47075

SHGC-57503 (e-PCR)
- UniSTS:19950

SHGC-57963 (e-PCR)
- UniSTS:73459

PMC97615P1 (e-PCR)
- UniSTS:273655

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: rho GTPase-activating protein 7

Names: deleted in liver cancer 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

21339822..21867217 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016959113.4 → XP_016814602.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A2J8K4B9, A0A6D2X7G3, H2QVS0, K7BZB1

Related

ENSPTRP00000034252.5

Conserved Domains (3) summary

cd08908
Location:1315 → 1518

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:454 → 513

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1072 → 1290

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_016959114.3 → XP_016814603.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A2J8K4B9, A0A6D2X7G3, H2QVS0, K7BZB1

Conserved Domains (3) summary

cd08908
Location:1315 → 1518

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:454 → 513

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1072 → 1290

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_016959112.4 → XP_016814601.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A2J8K4B9, A0A6D2X7G3, H2QVS0, K7BZB1

Conserved Domains (3) summary

cd08908
Location:1315 → 1518

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:454 → 513

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1072 → 1290

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_054656567.2 → XP_054512542.1 rho GTPase-activating protein 7 isoform X4

UniProtKB/TrEMBL

A0A2I3S289, A0A2J8K4C3
XM_016959115.4 → XP_016814604.1 rho GTPase-activating protein 7 isoform X2

UniProtKB/TrEMBL

A0A2I3RC10, A0A2I3S289, A0A2J8K4C5, A0A6D2WHD5

Related

ENSPTRP00000062181.1

Conserved Domains (3) summary

cd08908
Location:912 → 1115

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:51 → 110

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:669 → 887

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_063816886.1 → XP_063672956.1 rho GTPase-activating protein 7 isoform X5

UniProtKB/TrEMBL

A0A2I3S289
XM_016959116.3 → XP_016814605.1 rho GTPase-activating protein 7 isoform X3

UniProtKB/TrEMBL

A0A2I3S289, A0A2J8K4C7, A0A6D2WWH4, K7CBG6

Related

ENSPTRP00000090541.1

Conserved Domains (4) summary

cd08908
Location:878 → 1081

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09591
Location:17 → 76

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:635 → 853

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

pfam04520
Location:113 → 188

Senescence_reg; Senescence regulator
XM_063816885.1 → XP_063672955.1 rho GTPase-activating protein 7 isoform X5

UniProtKB/TrEMBL

A0A2I3S289
XM_016959117.3 → XP_016814606.1 rho GTPase-activating protein 7 isoform X4

UniProtKB/TrEMBL

A0A2I3S289, A0A2J8K4C3

Conserved Domains (2) summary

cd08908
Location:804 → 1007

START_STARD12-like; C-terminal lipid-binding START domain of mammalian STARD12 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd04375
Location:561 → 779

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
XM_054656571.2 → XP_054512546.1 rho GTPase-activating protein 7 isoform X8

UniProtKB/TrEMBL

A0A2I3S289
XM_054656569.2 → XP_054512544.1 rho GTPase-activating protein 7 isoform X6

UniProtKB/TrEMBL

A0A2I3SY84, A0A2J8K4C1, A0A6D2WHB2
XM_054656570.2 → XP_054512545.1 rho GTPase-activating protein 7 isoform X7
XM_054656568.2 → XP_054512543.1 rho GTPase-activating protein 7 isoform X6

UniProtKB/TrEMBL

A0A2I3SY84, A0A2J8K4C1, A0A6D2WHB2