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Pex1 Peroxin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45460, updated on 10-May-2024

Summary

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Official Symbol
Pex1provided by FlyBase
Official Full Name
Peroxin 1provided by FlyBase
Primary source
FLYBASE:FBgn0013563
Locus tag
Dmel_CG6760
See related
AllianceGenome:FB:FBgn0013563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0848/07; anon-WO0172774.100; anon-WO0172774.101; anon-WO0172774.102; anon-WO0172774.96; anon-WO0172774.98; anon-WO0172774.99; CG6760; DmCAB51031.1; DmelPex1; Dmel\CG6760; l(3)02402; l(3)084807; l(3)70Da; l(3)S084807; l(3)s4868; pex1; PEX1
Summary
Predicted to enable ATP hydrolysis activity. Involved in nervous system development; peroxisome organization; and spermatocyte division. Located in peroxisome. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; extended germ band embryo; spermatozoon; and yolk. Used to study Zellweger syndrome. Human ortholog(s) of this gene implicated in Heimler syndrome 1; infantile Refsum disease; and peroxisome biogenesis disorder 1A. Orthologous to human PEX1 (peroxisomal biogenesis factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pex1 in Genome Data Viewer
Location:
70D1-70D2; 3-42 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14071892..14076123)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14064992..14069223)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46067 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Formin-like Neighboring gene breathless Neighboring gene uncharacterized protein Neighboring gene Fat body protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Versatility of peroxisomes: An evolving concept. Deb R, et al. Tissue Cell, 2017 Apr. PMID 28347500
  2. Midlife gene expressions identify modulators of aging through dietary interventions. Zhou B, et al. Proc Natl Acad Sci U S A, 2012 May 8. PMID 22509016, Free PMC Article
  3. The role of Peroxin 7 during Drosophila embryonic development. Pridie C, et al. Genome, 2021 Feb. PMID 32191843
  4. Genetic and molecular analysis in the 70CD region of the third chromosome of Drosophila melanogaster. Burmester T, et al. Gene, 2000 Apr 4. PMID 10767537
  5. The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation. Russell SR, et al. Development, 1996 Nov. PMID 8951082

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peroxisome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peroxisome organization ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein import into peroxisome matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatocyte division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
peroxin 1
Names
CG6760-PA
Pex1-PA
lethal (3) 70Da

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14071892..14076123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143759.3 → NP_652016.1  peroxin 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652016.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUC7, Q9Y090
    Related
    FBpp0075519
    Conserved Domains (4) summary
    COG0464
    Location:479 → 974
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:757 → 887
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09262
    Location:93 → 168
    PEX-1N; Peroxisome biogenesis factor 1, N-terminal
    cl21455
    Location:480 → 604
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VUC7 Q9VUC7
Q9Y090 Q9Y090

Gene LinkOut

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