KARS1 lysyl-tRNA synthetase 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: KARS1provided by VGNC
Official Full Name: lysyl-tRNA synthetase 1provided by VGNC
Primary source: VGNC:VGNC:13722
Locus tag: CK820_G0042707
See related: Ensembl:ENSPTRG00000008364
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as: KARS
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 16

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	18	NC_072416.2 (73741314..73761314, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	16	NC_072414.1 (73741220..73761220, complement)

Chromosome 18 - NC_072416.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

SHGC-61037 (e-PCR)
- UniSTS:29953

SHGC-61044 (e-PCR)
- UniSTS:35439

D16S2968 (e-PCR)
- UniSTS:3283

RH103951 (e-PCR)
- UniSTS:98276

MARC_13466-13467:1002299828:1 (e-PCR)
- UniSTS:267500

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP:ADP adenylyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables lysine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables tRNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in basophil activation involved in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in diadenosine tetraphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lysyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of macrophage activation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: lysine--tRNA ligase

XP_003315273.1

EC 6.1.1.6

XP_009429550.1

EC 6.1.1.6

XP_063653520.1

EC 6.1.1.6

XP_063653521.1

EC 6.1.1.6

XP_063653522.1

EC 6.1.1.6

XP_063653523.1

EC 6.1.1.6

XP_063653524.1

EC 6.1.1.6

XP_511115.2

EC 6.1.1.6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072416.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

73741314..73761314 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063797452.1 → XP_063653522.1 lysine--tRNA ligase isoform X3
XM_511115.6 → XP_511115.2 lysine--tRNA ligase isoform X2

UniProtKB/TrEMBL

A0A2J8Q667, A0A5S6RD16, H2QBJ2

Related

ENSPTRP00000014279.2

Conserved Domains (4) summary

PLN02502
Location:26 → 591

PLN02502; lysyl-tRNA synthetase

cd00775
Location:251 → 589

LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...

cd04322
Location:139 → 248

LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

pfam08496
Location:31 → 60

Peptidase_S49_N; Peptidase family S49 N-terminal
XM_063797453.1 → XP_063653523.1 lysine--tRNA ligase isoform X3
XM_003315225.5 → XP_003315273.1 lysine--tRNA ligase isoform X1

See identical proteins and their annotated locations for XP_003315273.1

UniProtKB/TrEMBL

A0A2I3RWT8, A0A2J8Q670, A0A5S6R832, H2QBJ3

Related

ENSPTRP00000069187.1

Conserved Domains (1) summary

PLN02502
Location:48 → 605

PLN02502; lysyl-tRNA synthetase
XM_009431275.2 → XP_009429550.1 lysine--tRNA ligase isoform X1

See identical proteins and their annotated locations for XP_009429550.1

UniProtKB/TrEMBL

A0A2I3RWT8, A0A2J8Q670, A0A5S6R832, H2QBJ3

Related

ENSPTRP00000014280.4

Conserved Domains (1) summary

PLN02502
Location:48 → 605

PLN02502; lysyl-tRNA synthetase
XM_063797451.1 → XP_063653521.1 lysine--tRNA ligase isoform X3
XM_063797454.1 → XP_063653524.1 lysine--tRNA ligase isoform X3
XM_063797450.1 → XP_063653520.1 lysine--tRNA ligase isoform X1

UniProtKB/TrEMBL

A0A2J8Q670, A0A5S6R832, H2QBJ3