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Spn43Aa Serpin 43Aa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45041, updated on 10-May-2024

Summary

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Official Symbol
Spn43Aaprovided by FlyBase
Official Full Name
Serpin 43Aaprovided by FlyBase
Primary source
FLYBASE:FBgn0024294
Locus tag
Dmel_CG12172
See related
AllianceGenome:FB:FBgn0024294
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118057.1; CG12172; Dmel\CG12172; Ser1; SER1; Spn43 Aa; Spn43A
Summary
Predicted to be involved in negative regulation of proteolysis. Located in cytoplasm. Is expressed in early extended germ band embryo; embryonic dorsal epidermis; foregut; and labral segment. Human ortholog(s) of this gene implicated in familial encephalopathy with neuroserpin inclusion bodies; intermediate coronary syndrome; thrombophilia (multiple); thrombosis; and toxic shock syndrome. Orthologous to human SERPINB1 (serpin family B member 1); SERPINC1 (serpin family C member 1); and SERPINI1 (serpin family I member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Spn43Aa in Genome Data Viewer
Location:
42F2-42F3; 2-55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7147692..7149289)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3035197..3036794)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44443 Neighboring gene Cytochrome P450 9b2 Neighboring gene long non-coding RNA:CR44200 Neighboring gene uncharacterized protein Neighboring gene Serpin 43Ab Neighboring gene prickle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The necrotic gene in Drosophila corresponds to one of a cluster of three serpin transcripts mapping at 43A1.2. Green C, et al. Genetics, 2000 Nov. PMID 11063688, Free PMC Article
  2. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Gubb D, et al. Genes Dev, 1999 Sep 1. PMID 10485852, Free PMC Article
  3. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Levashina EA, et al. Science, 1999 Sep 17. PMID 10489372
  4. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
  5. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
serpin 43Aa
Names
CG12172-PA
Spn43Aa-PA
serine protease inhibitor 1
serine protease inhibitor 43Aa

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7147692..7149289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080066.3 → NP_524805.1  serpin 43Aa [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KA66, Q8MQZ7
    Related
    FBpp0088112
    Conserved Domains (1) summary
    cd00172
    Location:28 → 387
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KA66 Q7KA66
Q8MQZ7 Q8MQZ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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