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galca galactosylceramidase a [ Danio rerio (zebrafish) ]

Gene ID: 449649, updated on 27-Mar-2024

Summary

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Official Symbol
galcaprovided by ZNC
Official Full Name
galactosylceramidase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040724-243
See related
Ensembl:ENSDARG00000037064 AllianceGenome:ZFIN:ZDB-GENE-040724-243
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
galc; galcl; zgc:92561; si:ch211-199l3.4
Summary
Enables galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Predicted to act upstream of or within lipid catabolic process and sphingolipid metabolic process. Located in lysosome. Is expressed in central nervous system and yolk syncytial layer. Human ortholog(s) of this gene implicated in Krabbe disease. Orthologous to human GALC (galactosylceramidase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See galca in Genome Data Viewer
Location:
chromosome: 20
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (4769762..4793269, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (4726849..4750356, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene poly(A) polymerase alpha Neighboring gene adenylate kinase 7a Neighboring gene galectin 8a Neighboring gene zinc finger DHHC-type palmitoyltransferase 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and knockdown of galactocerebrosidase in zebrafish: new insights into the pathogenesis of Krabbe's disease. Zizioli D, et al. Biochim Biophys Acta, 2014 Apr. PMID 24463171
  2. β-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide Metabolism. Belleri M, et al. Cancer Res, 2020 Nov 15. PMID 32998995
  3. Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. Chen J, et al. Toxicology, 2012 Dec 16. PMID 23000284, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables galactosylceramidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylceramidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosylceramidase activity IEA
Inferred from Electronic Annotation
more info
  
enables galactosylceramidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in galactosylceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within galactosylceramide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in galactosylceramide catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galactocerebrosidase
Names
GALCERase
galactosylceramidase like
NP_001005921.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005921.1 → NP_001005921.1  galactocerebrosidase precursor

    See identical proteins and their annotated locations for NP_001005921.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083517
    UniProtKB/Swiss-Prot
    Q5SNX7, Q5XJ01
    Related
    ENSDARP00000053869.4, ENSDART00000053870.6
    Conserved Domains (2) summary
    pfam02057
    Location:21 → 659
    Glyco_hydro_59; Glycosyl hydrolase family 59
    cl23815
    Location:116 → 304
    Glyco_hydro_30; O-Glycosyl hydrolase family 30

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    4769762..4793269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SNX7.1 GenPept UniProtKB/Swiss-Prot:Q5SNX7

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