U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

raw raw [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44851, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
rawprovided by FlyBase
Official Full Name
rawprovided by FlyBase
Primary source
FLYBASE:FBgn0003209
Locus tag
Dmel_CG12437
See related
AllianceGenome:FB:FBgn0003209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12437; CG9321; cyr; Dmel\CG12437; ensh; l(2)06825; l(2)k03514; Raw
Summary
Involved in several processes, including animal organ morphogenesis; embryonic morphogenesis; and negative regulation of JNK cascade. Located in plasma membrane. Is expressed in embryonic/larval midgut; epithelium; midgut primordium; and presumptive embryonic/larval central nervous system. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See raw in Genome Data Viewer
Location:
29E4-29E6; 2-33 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8709880..8740660, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8709880..8740660, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Hepatocyte nuclear factor 4 Neighboring gene antisense RNA:CR44992 Neighboring gene Catalase B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Raw regulates glial population of the eye imaginal disc. Hans VR, et al. Genesis, 2018 Oct. PMID 30288928
  2. Identification of raw as a regulator of glial development. Luong D, et al. PLoS One, 2018. PMID 29813126, Free PMC Article
  3. ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeleton. Blake KJ, et al. Dev Genes Evol, 1999 Sep. PMID 10502112
  4. The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in Drosophila. Blake KJ, et al. Dev Biol, 1998 Nov 1. PMID 9806782
  5. The genes raw and ribbon are required for proper shape of tubular epithelial tissues in Drosophila. Jack J, et al. Genetics, 1997 Sep. PMID 9286684, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The membrane protein Raw regulates dendrite pruning via the secretory pathway.
    Title: The membrane protein Raw regulates dendrite pruning via the secretory pathway.
  2. This study reports the identification of a new regulator of axonal degeneration: the transmembrane protein Raw. Raw regulates a cell autonomous nuclear signaling pathway whose yet unknown downstream effectors protect injured axons, dendrites, and synapses from degenerating
    Title: Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw.
  3. Raw is required for glial proliferation and migration in the developing visual system
    Title: Raw regulates glial population of the eye imaginal disc.
  4. raw as a regulator of glial development
    Title: Identification of raw as a regulator of glial development.
  5. Raw defines a potential point of convergence in distinct pathways shaping terminal dendrite patterning.
    Title: Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw.
  6. loss of DE-cadherin strongly enhances the raw mutant gonad phenotype, while increasing DE-cadherin function rescues this phenotype
    Title: raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis.
  7. In Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) signaling cascade.
    Title: Raw mediates antagonism of AP-1 activity in Drosophila.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: c8731490-8723170 mobile_element_type = transposon:Tirant{}328

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ectodermal digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-band shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Malpighian tubule diameter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
raw
Names
CG12437-PA
CG12437-PB
CG12437-PC
CG12437-PD
CG12437-PE
cyrano
ensheathment defects
raw-PA
raw-PB
raw-PC
raw-PD
raw-PE

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8709880..8740660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080050.3 → NP_524789.2  raw, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524789.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3Z6, Q9VLI5
    Related
    FBpp0079347
    Conserved Domains (1) summary
    pfam15891
    Location:168 → 257
    Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like

  2. NM_001201804.1 → NP_001188733.1  raw, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188733.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NJ08, Q9VLI4
    Conserved Domains (1) summary
    pfam15891
    Location:352 → 441
    Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like

  3. NM_164836.3 → NP_723416.1  raw, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723416.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NJ08, Q9VLI4
    Related
    FBpp0079348
    Conserved Domains (1) summary
    pfam15891
    Location:352 → 441
    Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like

  4. NM_001298831.1 → NP_001285760.1  raw, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285760.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NJ08, Q9VLI4
    Conserved Domains (1) summary
    pfam15891
    Location:352 → 441
    Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like

  5. NM_001298830.1 → NP_001285759.1  raw, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285759.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3Z6, X2J5A2
    Conserved Domains (1) summary
    pfam15891
    Location:195 → 284
    Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MT71 Q8MT71
Q9NJ08 Q9NJ08
Q9U3Z6 Q9U3Z6
Q9VLI4 Q9VLI4
Q9VLI5 Q9VLI5
X2J5A2 X2J5A2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools