m miniature [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mprovided by FlyBase
Official Full Name: miniatureprovided by FlyBase
Primary source: FLYBASE:FBgn0002577
Locus tag: Dmel_CG9369
See related: AllianceGenome:FB:FBgn0002577
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9369; Dmel\CG9369; M; min; Min
Summary: Predicted to be a structural constituent of chitin-based cuticle. Involved in several processes, including cuticle pattern formation; epithelial cell differentiation; and regulation of embryonic cell shape. Located in apical plasma membrane. Is expressed in trichome. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11754273..11769508)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11648306..11663541)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Extracellular matrix protein Miniature is essential for proper progress of apoptosis and, presumably, epithelial-to-mesenchymal transition.
Title: The downregulation of the miniature gene does not replicate miniature loss-of-function phenotypes in Drosophila melanogaster wing to the full extent.
Miniature acts upstream from the heterotrimeric Gs protein transducing the bursicon signal in wing epithelia.
Title: Role of the gene Miniature in Drosophila wing maturation.
functions as structural component of the Drosophila cuticulin layer
Title: Molecular analysis of the Drosophila miniature-dusky ( m-dy) gene complex: m-dy mRNAs encode transmembrane proteins with similarity to C. elegans cuticulin.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables structural constituent of chitin-based cuticle	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical constriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain