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myo6a myosin VIa [ Danio rerio (zebrafish) ]

Gene ID: 445473, updated on 18-Sep-2024

Summary

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Official Symbol
myo6aprovided by ZNC
Official Full Name
myosin VIaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040819-2
See related
Ensembl:ENSDARG00000044016 AllianceGenome:ZFIN:ZDB-GENE-040819-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within angioblast cell migration from lateral mesoderm to midline and artery morphogenesis. Predicted to be located in several cellular components, including clathrin-coated pit; filopodium; and ruffle membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including endocytic vesicle; microvillus; and ruffle. Is expressed in dorsal aorta; neural tube; posterior cardinal vein; and somite. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See myo6a in Genome Data Viewer
Location:
chromosome: 20
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (715717..777219)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (694859..756393)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene neural retina leucine zipper Neighboring gene SUMO specific peptidase 6a Neighboring gene interphotoreceptor matrix proteoglycan 1 Neighboring gene meiosis-specific, MEI4 homolog (S. cerevisiae) Neighboring gene 5'-nucleotidase, ecto (CD73)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional Characterization of the MYO6 Variant p.E60Q in Non-Syndromic Hearing Loss Patients. Alkowari M, et al. Int J Mol Sci, 2022 Mar 21. PMID 35328790, Free PMC Article
  2. Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafish. Seiler C, et al. Dev Biol, 2004 Aug 15. PMID 15282151
  3. A nonsense mutation in the gene encoding a zebrafish myosin VI isoform causes defects in hair-cell mechanotransduction. Kappler JA, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15317943, Free PMC Article
  4. VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Lanahan AA, et al. Dev Cell, 2010 May 18. PMID 20434959, Free PMC Article
  5. Expression of unconventional myosin genes during neuronal development in zebrafish. Sittaramane V, et al. Gene Expr Patterns, 2008 Feb. PMID 18078791, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angioblast cell migration from lateral mesoderm to midline IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within auditory receptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner ear auditory receptor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner ear morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within otic vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within otolith development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to auditory stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microvillus IEA
Inferred from Electronic Annotation
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin VIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004111.2 → NP_001004111.2  myosin VIa

    Status: VALIDATED

    Source sequence(s)
    CU469066
    UniProtKB/TrEMBL
    A0A8M9PH95, E9QCU8
    Related
    ENSDARP00000112958.1, ENSDART00000135066.3
    Conserved Domains (3) summary
    cd01382
    Location:71 → 758
    MYSc_Myo6; class VI myosin, motor domain
    pfam02736
    Location:4 → 32
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam16521
    Location:1171 → 1261
    Myosin-VI_CBD; Myosin VI cargo binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    715717..777219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468404.2 → XP_021324079.1  myosin VIa isoform X1

    UniProtKB/TrEMBL
    A0A8M9PH95, E9QCU8
    Conserved Domains (3) summary
    cd01382
    Location:71 → 758
    MYSc_Myo6; class VI myosin, motor domain
    pfam02736
    Location:4 → 32
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam16521
    Location:1171 → 1261
    Myosin-VI_CBD; Myosin VI cargo binding domain

  2. XM_005160309.5 → XP_005160366.1  myosin VIa isoform X2

    UniProtKB/TrEMBL
    A0A8M2B757
    Conserved Domains (3) summary
    smart00242
    Location:59 → 770
    MYSc; Myosin. Large ATPases
    cd01382
    Location:71 → 758
    MYSc_Myo6; class VI myosin, motor domain
    pfam16521
    Location:1161 → 1251
    Myosin-VI_CBD; Myosin VI cargo binding domain

  3. XM_068215418.1 → XP_068071519.1  myosin VIa isoform X3

  4. XM_068215419.1 → XP_068071520.1  myosin VIa isoform X4

  5. XM_068215420.1 → XP_068071521.1  myosin VIa isoform X5

  6. XM_005160311.5 → XP_005160368.1  myosin VIa isoform X6

    UniProtKB/TrEMBL
    A0A8M2B747, F1Q6Q6
    Related
    ENSDARP00000115756.1, ENSDART00000136768.3
    Conserved Domains (3) summary
    smart00242
    Location:59 → 770
    MYSc; Myosin. Large ATPases
    cd01382
    Location:71 → 758
    MYSc_Myo6; class VI myosin, motor domain
    pfam16521
    Location:1136 → 1226
    Myosin-VI_CBD; Myosin VI cargo binding domain
Nucleotide Protein Strain
Heading Accession and Version

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