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stx2a syntaxin 2a [ Danio rerio (zebrafish) ]

Gene ID: 445167, updated on 12-Sep-2024

Summary

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Official Symbol
stx2aprovided by ZNC
Official Full Name
syntaxin 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-80
See related
Ensembl:ENSDARG00000004618 AllianceGenome:ZFIN:ZDB-GENE-040801-80
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fk28f06; wu:fk28f06; zgc:101111
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; synaptic vesicle fusion to presynaptic active zone membrane; and vesicle docking. Predicted to act upstream of or within acrosome reaction; cell differentiation; and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in presynaptic active zone membrane and synaptic vesicle. Predicted to be integral component of membrane. Orthologous to human STX2 (syntaxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (17951286..17956563, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (17914648..17920098, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene gelsolin a Neighboring gene retinoid X receptor, alpha a Neighboring gene uncharacterized LOC110438227 Neighboring gene dynein, axonemal, intermediate chain 1, paralog 2 Neighboring gene uncharacterized LOC137488794

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
syntaxin 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003561.1 → NP_001003561.1  syntaxin 2a

    See identical proteins and their annotated locations for NP_001003561.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077121
    UniProtKB/TrEMBL
    Q6DEJ2
    Related
    ENSDARP00000005867.8, ENSDART00000026737.10
    Conserved Domains (3) summary
    cd15848
    Location:125 → 187
    SNARE_syntaxin1-like; SNARE motif of syntaxin 1 and related proteins
    pfam00804
    Location:25 → 161
    Syntaxin; Syntaxin
    cl00143
    Location:25 → 89
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    17951286..17956563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161168.5 → XP_005161225.1  syntaxin 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M2B849, E9QCC0
    Related
    ENSDARP00000123358.1, ENSDART00000148154.2
    Conserved Domains (3) summary
    cd00179
    Location:25 → 178
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15848
    Location:188 → 250
    SNARE_syntaxin1-like; SNARE motif of syntaxin 1 and related proteins
    pfam00804
    Location:25 → 224
    Syntaxin; Syntaxin
Nucleotide Protein Strain
Heading Accession and Version

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