pltp phospholipid transfer protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pltpprovided by ZNC
Official Full Name: phospholipid transfer proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-22
See related: Ensembl:ENSDARG00000104495 AllianceGenome:ZFIN:ZDB-GENE-040801-22
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:100903
Summary: Predicted to enable several functions, including diacylglycerol binding activity; lipid transfer activity; and phospholipid binding activity. Predicted to be involved in ceramide transport; high-density lipoprotein particle remodeling; and phospholipid transport. Predicted to act upstream of or within lipid metabolic process. Predicted to be active in extracellular space. Orthologous to human PLTP (phospholipid transfer protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (55357149..55393312)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (55347345..55383499)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ceramide transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine transfer activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ceramide transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipid transfer protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003519.1 → NP_001003519.1 phospholipid transfer protein precursor

See identical proteins and their annotated locations for NP_001003519.1

Status: PROVISIONAL

Source sequence(s)

BC077135

UniProtKB/TrEMBL

A0A8M1N1H3, Q6DEI0

Related

ENSDARP00000131164.1, ENSDART00000169240.2

Conserved Domains (2) summary

smart00328
Location:28 → 241

BPI1; BPI/LBP/CETP N-terminal domain

cl00188
Location:232 → 466

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

55357149..55393312

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168776.5 → XP_005168833.1 phospholipid transfer protein isoform X1

See identical proteins and their annotated locations for XP_005168833.1

UniProtKB/TrEMBL

A0A8M1N1H3, Q6DEI0

Conserved Domains (2) summary

smart00328
Location:28 → 241

BPI1; BPI/LBP/CETP N-terminal domain

cl00188
Location:232 → 466

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
XM_068221697.1 → XP_068077798.1 phospholipid transfer protein isoform X1