Xbp1 X box binding protein-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Xbp1provided by FlyBase
Official Full Name: X box binding protein-1provided by FlyBase
Primary source: FLYBASE:FBgn0021872
Locus tag: Dmel_CG9415
See related: AllianceGenome:FB:FBgn0021872
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 138/3; anon-EST:Liang-1.41; CG 9415; CG9415; clone 1.41; DM18; Dmel\CG9415; dmXBP1; dXbp-1; Dxbp-1; l(2)k13803; sXbp1; xbp-1; Xbp-1; XBP-1; xbp1; XBP1; XbpI
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in intestinal stem cell homeostasis; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; and regulation of translation in response to endoplasmic reticulum stress. Predicted to be active in nucleus. Is expressed in several structures, including adult antennal olfactory receptor neurons; embryonic epidermis; embryonic/larval plasmatocyte; extended germ band embryo; and gut. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 57C3-57C4; 2-93 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21143545..21145750)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17031050..17033255)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila.
Title: The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila.
Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1.
Title: Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1.
Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay.
Title: Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay.
X-box binding protein 1 overexpression at an early stage reversed Abeta-induced early death without affecting learning performance in the Abeta42 transgenic flies. PERK activation was determined to only enhance Abeta-induced learning deficits.
Title: XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology.
XBP1-independent IRE1 RNase activity, while challenging the importance of RNase-independent effector mechanisms of Drosophila IRE1 function.
Title: The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development.
Its activation is neuroprotective and enhances Abeta42 clearance.
Title: Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain.
Ire1-dependent splicing of Xbp1 mRNA is reduced.
Title: Ire1 mediated mRNA splicing in a C-terminus deletion mutant of Drosophila Xbp1.
role of Ire1 during photoreceptor differentiation is independent of Xbp1 function and demonstrate the physiological relevance of the RIDD mechanism in this specific paradigm.
Title: Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila.
The XBP1 promoter activity is enhanced in secretory tissues of Drosophila, and can be induced by excessive endoplasmic reticulum stress.
Title: Drosophila XBP1 expression reporter marks cells under endoplasmic reticulum stress and with high protein secretory load.
In the larval brain, IRE1/XBP1 activity was detected exclusively in glia, although previous reports have largely focused on IRE1/XBP1 activity in neurons.
Title: A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	TAS Traceable Author Statement more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in intestinal stem cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	HMP more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride mobilization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: X box binding protein-1

Names: CG9415-PD; CG9415-PE; X box binding protein 1; X-box binding protein; X-box protein 1; X-box-binding protein 1; Xbp1-PD; Xbp1-PE

NP_726032.4

unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

21143545..21145750

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166427.4 → NP_726032.4 X box binding protein-1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726032.4

Status: REVIEWED

UniProtKB/TrEMBL

Q8MLW7

Conserved Domains (2) summary

cd14691
Location:81 → 138

bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain

cl09111
Location:114 → 167

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_079983.4 → NP_524722.2 X box binding protein-1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524722.2

Status: REVIEWED

UniProtKB/TrEMBL

Q5BI44

Related

FBpp0301745

Conserved Domains (1) summary

cd14691
Location:81 → 138

bZIP_XBP1; Basic leucine zipper (bZIP) domain of X-box binding protein 1 (XBP1) and similar proteins: a DNA-binding and dimerization domain