U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

faf fat facets [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43749, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
fafprovided by FlyBase
Official Full Name
fat facetsprovided by FlyBase
Primary source
FLYBASE:FBgn0005632
Locus tag
Dmel_CG1945
See related
AllianceGenome:FB:FBgn0005632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA.LD22582; BcDNA:LD22582; CG1945; Dmel\CG1945; Faf; FAF; Fat; P55824; USPX
Summary
Enables thiol-dependent deubiquitinase. Involved in several processes, including mystery cell differentiation; nuclear cortical migration; and proteolysis. Located in cytoplasm. Is expressed in several structures, including embryonic/larval digestive system; embryonic/larval fat body; gonad; imaginal disc; and visual system. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2; female-restricted syndromic X-linked intellectual disability 99; and non-syndromic X-linked intellectual disability 99. Orthologous to several human genes including USP9X (ubiquitin specific peptidase 9 X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
100D2-100D2; 3-102 cM
Exon count:
21
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31777020..31790681)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27602742..27616403)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR33945 Neighboring gene beta glucuronidase Neighboring gene septin interacting protein 3 Neighboring gene uncharacterized protein Neighboring gene Methylcrotonoyl-CoA carboxylase 1 Neighboring gene ATP-dependent chromatin assembly factor large subunit Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 100a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deubiquitinases in Neurodegeneration. Bello AI, et al. Cells, 2022 Feb 5. PMID 35159365, Free PMC Article
  2. Protein degradation: de-ubiquitinate to decide your fate. Kalderon D. Curr Biol, 1996 Jun 1. PMID 8793288
  3. La FAM fatale: USP9X in development and disease. Murtaza M, et al. Cell Mol Life Sci, 2015 Jun. PMID 25672900, Free PMC Article
  4. Identification of Genes that Maintain Behavioral and Structural Plasticity during Sleep Loss. Seugnet L, et al. Front Neural Circuits, 2017. PMID 29109678, Free PMC Article
  5. Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes. Millard SM, et al. J Cell Biol, 2006 May 22. PMID 16702236, Free PMC Article

See all (158) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that the ability of faf, hiw or Rdl to modulate sleep and protect against cognitive impairments during waking is circuit dependent. Decreasing hiw and Rdl within the Mushroom Bodies protects against the negative effects of sleep deprivation as indicated by the absence of a subsequent homeostatic response, or deficits in short-term memory.
    Title: Identification of Genes that Maintain Behavioral and Structural Plasticity during Sleep Loss.
  2. Faf inhibits the IMD pathway by modulating the state of Imd ubiquitination and/or stability.
    Title: fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila.
  3. Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient
    Title: Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient.
  4. By deubiquitinating Lqf, which enhances the efficiency of Delta internalization, Faf stimulates Delta signaling
    Title: Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellularization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in dorsal/ventral axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in mystery cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of innate immune response HMP PubMed 
involved_in nuclear cortical migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
fat facets
Names
CG1945-PA
CG1945-PC
CG1945-PD
CG1945-PE
CG1945-PG
CG1945-PH
CG1945-PI
Fat facets
Fat-Facets
faf-PA
faf-PC
faf-PD
faf-PE
faf-PG
faf-PH
faf-PI
NP_001247387.1
NP_001247388.1
NP_001247389.2
NP_001247390.1
NP_001287627.1
NP_524612.2
NP_733455.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31777020..31790681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260460.2 → NP_001247389.2  fat facets, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247389.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6W2
    Conserved Domains (2) summary
    cd02659
    Location:1666 → 2064
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1668 → 2059
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. NM_079873.5 → NP_524612.2  fat facets, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524612.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55824, Q9V9T6, Q9Y0Z7
    Related
    FBpp0085202
    Conserved Domains (2) summary
    cd02659
    Location:1666 → 2064
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1668 → 2059
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. NM_001300698.1 → NP_001287627.1  fat facets, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287627.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7S0
    Conserved Domains (2) summary
    cd02659
    Location:1666 → 2064
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1668 → 2059
    UCH; Ubiquitin carboxyl-terminal hydrolase

  4. NM_170576.3 → NP_733455.1  fat facets, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733455.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55824
    Related
    FBpp0085203
    Conserved Domains (2) summary
    cd02659
    Location:1666 → 2064
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1668 → 2059
    UCH; Ubiquitin carboxyl-terminal hydrolase

  5. NM_001260459.1 → NP_001247388.1  fat facets, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247388.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6W2
    Conserved Domains (2) summary
    cd02659
    Location:1666 → 2064
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1668 → 2059
    UCH; Ubiquitin carboxyl-terminal hydrolase

  6. NM_001260461.1 → NP_001247390.1  fat facets, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247390.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7S0
    Conserved Domains (2) summary
    cd02659
    Location:1666 → 2064
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1668 → 2059
    UCH; Ubiquitin carboxyl-terminal hydrolase

  7. NM_001260458.1 → NP_001247387.1  fat facets, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247387.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7S0
    Conserved Domains (2) summary
    cd02659
    Location:1666 → 2064
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1668 → 2059
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6W2 A0A0B4K6W2
A0A0B4K7S0 A0A0B4K7S0
P55824.2 P55824

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous