U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pHCl-2 pH-sensitive chloride channel 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43703, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
pHCl-2provided by FlyBase
Official Full Name
pH-sensitive chloride channel 2provided by FlyBase
Primary source
FLYBASE:FBgn0039840
Locus tag
Dmel_CG11340
See related
AllianceGenome:FB:FBgn0039840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11340; CT5896; Dmel\CG11340; hodor; Lcch-100C; lincRNA.914; pHCL-2
Summary
Enables ion channel activity and zinc ion sensor activity. Involved in several processes, including cellular response to zinc ion; chloride transmembrane transport; and positive regulation of signal transduction. Located in apical plasma membrane; bounding membrane of organelle; and brush border membrane. Part of transmembrane transporter complex. Is expressed in Malpighian tubule; adult central nervous system; and midgut. Human ortholog(s) of this gene implicated in hyperekplexia 2. Orthologous to human GLRB (glycine receptor beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
100C1-100C1; 3-102 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31300918..31305384, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27128211..27131106, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase 5 Neighboring gene pickpocket 24 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46118 Neighboring gene gasket

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules. Feingold D, et al. J Exp Biol, 2016 Sep 1. PMID 27358471
  2. Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria. Dent JA. J Mol Evol, 2006 May. PMID 16586016
  3. Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster. Remnant EJ, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172217, Free PMC Article
  4. Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion. Witte I, et al. J Neurochem, 2002 Nov. PMID 12390512
  5. An intestinal zinc sensor regulates food intake and developmental growth. Redhai S, et al. Nature, 2020 Apr. PMID 32269334, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identification of Hodor, an ionotropic receptor in enterocytes that sustains larval development, particularly in nutrient-scarce conditions; experiments in Xenopus oocytes and flies indicate that Hodor is a pH-sensitive, zinc-gated chloride channel that mediates a previously unrecognized dietary preference for zinc
    Title: An intestinal zinc sensor regulates food intake and developmental growth.
  2. Ligand-gated chloride channels have established roles in inhibitory neurotransmission in the nervous systems of vertebrates and invertebrates. Paradoxically, expression databases in Drosophila melanogaster have revealed that three uncharacterized ligand-gated chloride channel subunits, CG7589, CG6927, and CG11340, are highly expressed in nonneuronal tissues.
    Title: Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pH-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion sensor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to zinc ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of renal water transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
pH-sensitive chloride channel 2
Names
CG11340-PA
CG11340-PB
glycine-gated chloride channel-like
hold on, don't rush
pHCl-2-PA
pHCl-2-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31300918..31305384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316541.1 → NP_001303470.1  pH-sensitive chloride channel 2, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E3CTP9, Q9V9Y4
    Conserved Domains (1) summary
    TIGR00860
    Location:46 → 522
    LIC; Cation transporter family protein

  2. NM_143604.3 → NP_651861.1  pH-sensitive chloride channel 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651861.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E3CTP9, Q9V9Y4
    Related
    FBpp0085128
    Conserved Domains (1) summary
    TIGR00860
    Location:46 → 522
    LIC; Cation transporter family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V9Y4.1 Q9V9Y4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous