U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Npc2g Niemann-Pick type C-2g [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43648, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Npc2gprovided by FlyBase
Official Full Name
Niemann-Pick type C-2gprovided by FlyBase
Primary source
FLYBASE:FBgn0039800
Locus tag
Dmel_CG11314
See related
AllianceGenome:FB:FBgn0039800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE56164; CG11314; Dmel\CG11314; npc2g
Summary
Predicted to enable sterol binding activity. Involved in mesoderm development. Located in extracellular region. Is expressed in adult head; adult heart; embryonic/larval fat body; and extended germ band embryo. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
100A3-100A3; 3-101 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30744605..30745263, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26570327..26570985, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43238 Neighboring gene Niemann-Pick type C-2h

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Hang S, et al. Cell Host Microbe, 2014 Nov 12. PMID 25525791, Free PMC Article
  2. The Effect of Common Inversion Polymorphisms In(2L)t and In(3R)Mo on Patterns of Transcriptional Variation in Drosophila melanogaster. Lavington E, et al. G3 (Bethesda), 2017 Nov 6. PMID 28916647, Free PMC Article
  3. Drosophila melanogaster NPC2 proteins bind bacterial cell wall components and may function in immune signal pathways. Shi XZ, et al. Insect Biochem Mol Biol, 2012 Aug. PMID 22580186, Free PMC Article
  4. Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Huang X, et al. Development, 2007 Oct. PMID 17804599
  5. TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior. Ng FS, et al. Front Mol Neurosci, 2016. PMID 28066175, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol binding IEA
Inferred from Electronic Annotation
more info
  
enables sterol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular cholesterol transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Niemann-Pick type C-2g
Names
CG11314-PA
CG11314-PB
Npc2g-PA
Npc2g-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30744605..30745263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143566.2 → NP_651823.1  Niemann-Pick type C-2g, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651823.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGP0, Q9VA42
    Related
    FBpp0085085
    Conserved Domains (1) summary
    cd00916
    Location:28 → 155
    Npc2_like; Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived ...

  2. NM_001260446.2 → NP_001247375.1  Niemann-Pick type C-2g, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247375.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGP0, Q9VA42
    Conserved Domains (1) summary
    cd00916
    Location:28 → 155
    Npc2_like; Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGP0 Q8IGP0
Q9VA42 Q9VA42

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools