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Alg13 Alg13 UDP-N-acetylglucosaminyltransferase subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43443, updated on 10-May-2024

Summary

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Official Symbol
Alg13provided by FlyBase
Official Full Name
Alg13 UDP-N-acetylglucosaminyltransferase subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0039639
Locus tag
Dmel_CG14512
See related
AllianceGenome:FB:FBgn0039639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14512; dAlg13; Dmel\CG14512
Summary
Predicted to contribute to N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 36. Orthologous to human ALG13 (ALG13 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Alg13 in Genome Data Viewer
Location:
98F12-98F12; 3-97 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29137970..29138573, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24963692..24964295, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Choline transporter-like 2 Neighboring gene dim gamma-tubulin 6 Neighboring gene Vacuolar H[+] ATPase 100kD subunit 1 Neighboring gene Suppressor of ER stress-induced death Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
  2. An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. Avet-Rochex A, et al. BMC Dev Biol, 2010 Jun 11. PMID 20540764, Free PMC Article
  3. Genome-Wide Mapping Targets of the Metazoan Chromatin Remodeling Factor NURF Reveals Nucleosome Remodeling at Enhancers, Core Promoters and Gene Insulators. Kwon SY, et al. PLoS Genet, 2016 Apr. PMID 27046080, Free PMC Article
  4. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
  5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of UDP-N-acetylglucosamine transferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Alg13 UDP-N-acetylglucosaminyltransferase subunit
Names
Alg13-PA
CG14512-PA
NP_651673.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29137970..29138573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143416.1 → NP_651673.1  Alg13 UDP-N-acetylglucosaminyltransferase subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651673.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29QL2, Q9VAP1
    Related
    FBpp0084782, FBtr0085413
    Conserved Domains (1) summary
    pfam04101
    Location:5 → 168
    Glyco_tran_28_C; Glycosyltransferase family 28 C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAP1 Q9VAP1

Gene LinkOut

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