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Sgpp2 sphingosine-1-phosphate phosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 433323, updated on 18-Sep-2024

Summary

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Official Symbol
Sgpp2provided by MGI
Official Full Name
sphingosine-1-phosphate phosphatase 2provided by MGI
Primary source
MGI:MGI:3589109
See related
Ensembl:ENSMUSG00000032908 AllianceGenome:MGI:3589109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spp2; SPPase2
Summary
Enables sphingosine-1-phosphate phosphatase activity. Involved in regulation of type B pancreatic cell proliferation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SGPP2 (sphingosine-1-phosphate phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 23.4), cerebellum adult (RPKM 20.7) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Sgpp2 in Genome Data Viewer
Location:
1 C4; 1 40.23 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78286186..78396926)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78309549..78420289)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Pax3 upstream hypaxial enhancer Neighboring gene predicted gene, 33152 Neighboring gene predicted gene 2102 Neighboring gene STARR-seq mESC enhancer starr_01424 Neighboring gene STARR-seq mESC enhancer starr_01425 Neighboring gene predicted gene, 51634 Neighboring gene STARR-seq mESC enhancer starr_01426 Neighboring gene STARR-positive B cell enhancer ABC_E4327 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene phenylalanyl-tRNA synthetase, beta subunit Neighboring gene STARR-positive B cell enhancer ABC_E9179 Neighboring gene STARR-seq mESC enhancer starr_01427 Neighboring gene STARR-positive B cell enhancer ABC_E5774 Neighboring gene STARR-positive B cell enhancer ABC_E322 Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene STARR-seq mESC enhancer starr_01430 Neighboring gene STARR-seq mESC enhancer starr_01431 Neighboring gene predicted gene, 57683

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation. Taguchi Y, et al. J Biol Chem, 2016 Jun 3. PMID 27059959, Free PMC Article
  2. Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney. Kirby RJ, et al. Am J Physiol Renal Physiol, 2009 Mar. PMID 19073640, Free PMC Article
  3. Spatiotemporal structure of cell fate decisions in murine neural crest. Soldatov R, et al. Science, 2019 Jun 7. PMID 31171666
  4. Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. López-Juárez A, et al. Glia, 2011 Apr. PMID 21319224, Free PMC Article
  5. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC59240

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dihydrosphingosine-1-phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine-1-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingosine-1-phosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sphingosine-1-phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sphingosine-1-phosphate phosphatase 2
Names
sphingosine-1-phosphatase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004173.2 → NP_001004173.1  sphingosine-1-phosphate phosphatase 2

    See identical proteins and their annotated locations for NP_001004173.1

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC124989, AK081023, BY234834, BY297240, CK389092
    Consensus CDS
    CCDS15083.1
    UniProtKB/Swiss-Prot
    B2RWL5, Q810K3
    Related
    ENSMUSP00000036656.9, ENSMUST00000036172.10
    Conserved Domains (1) summary
    cd03388
    Location:39 → 188
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    78286186..78396926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238695.3 → XP_011236997.1  sphingosine-1-phosphate phosphatase 2 isoform X4

    Conserved Domains (1) summary
    cd03388
    Location:39 → 171
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

  2. XM_030255370.2 → XP_030111230.1  sphingosine-1-phosphate phosphatase 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RWL5, Q810K3
    Conserved Domains (1) summary
    cd03388
    Location:39 → 188
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

  3. XM_030255371.2 → XP_030111231.1  sphingosine-1-phosphate phosphatase 2 isoform X2

    Conserved Domains (1) summary
    cd03388
    Location:29 → 135
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

  4. XM_017321596.3 → XP_017177085.1  sphingosine-1-phosphate phosphatase 2 isoform X3

    Conserved Domains (1) summary
    cd03388
    Location:1 → 105
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

RNA

  1. XR_373543.5 RNA Sequence

  2. XR_373544.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810K3.1 GenPept UniProtKB/Swiss-Prot:Q810K3

Gene LinkOut

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