U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG6420 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43218, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
CG6420provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039451
Locus tag
Dmel_CG6420
See related
AllianceGenome:FB:FBgn0039451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6420
Summary
Is expressed in adult head and organism. Orthologous to several human genes including WDR20 (WD repeat domain 20). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
97C5-97C5; 3-91 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26719847..26725216, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22545569..22550938, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Yip1-interacting factor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease. Lavoy S, et al. Genetics, 2018 Aug. PMID 29907646, Free PMC Article
  2. Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster. Dembeck LM, et al. PLoS Genet, 2015 May. PMID 25933381, Free PMC Article
  3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
  5. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables deubiquitinase activator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of peptidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG6420-PA
CG6420-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26719847..26725216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300616.1 → NP_001287545.1  uncharacterized protein Dmel_CG6420, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287545.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T4E0, Q9VBC4
    Conserved Domains (3) summary
    COG2319
    Location:193 → 509
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:284 → 330
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:297 → 417
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_143242.3 → NP_651499.2  uncharacterized protein Dmel_CG6420, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651499.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T4E0, Q9VBC4
    Related
    FBpp0084418
    Conserved Domains (3) summary
    COG2319
    Location:193 → 509
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:284 → 330
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:297 → 417
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBC4 Q9VBC4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous