qki.L QKI, KH domain containing, RNA binding L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: qki.L
Official Full Name: QKI, KH domain containing, RNA binding L homeolog
Primary source: Xenbase:XB-GENE-865618
Locus tag: XELAEV_18026846mg
See related: EnsemblRapid:ENSXLAG00005027988
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: qk; qk1; qki; Xqua; qki-a; qki-b; quaking
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5L

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (56472860..56598501)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (55243964..55368780)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Size exclusion chromatography studies of a range of mutants demonstrate that the dimeric state of the pXqua QUA1 domain is stabilized by a network of interactions between side-chains, with significant roles played by an intra-molecular hydrogen bond
Title: Solution structure of the QUA1 dimerization domain of pXqua, the Xenopus ortholog of Quaking.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: KH domain-containing RNA-binding protein qki.L; protein quaking-B

Names: quaking homolog, KH domain RNA binding

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091518.1 → NP_001084987.1 KH domain-containing RNA-binding protein qki.L

See identical proteins and their annotated locations for NP_001084987.1

Status: PROVISIONAL

Source sequence(s)

BC070801

UniProtKB/Swiss-Prot

Q32NN2, Q6IRN2

UniProtKB/TrEMBL

A0A974HJ83

Conserved Domains (3) summary

cd02395
Location:84 → 206

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

pfam16544
Location:10 → 68

STAR_dimer; Homodimerization region of STAR domain protein

pfam16551
Location:315 → 342

Quaking_NLS; Putative nuclear localization signal of quaking

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

56472860..56598501

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041562168.1 → XP_041418102.1 protein quaking-B isoform X3

UniProtKB/TrEMBL

A0A8J1KL98, A0A974CSQ1

Conserved Domains (2) summary

COG5176
Location:108 → 246

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

PRK14950
Location:235 → 345

PRK14950; DNA polymerase III subunits gamma and tau; Provisional
XM_041562167.1 → XP_041418101.1 protein quaking-B isoform X2

UniProtKB/TrEMBL

A0A8J1KLA7, A0A974CSQ1

Conserved Domains (1) summary

COG5176
Location:108 → 246

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
XM_041562170.1 → XP_041418104.1 protein quaking-B isoform X5

UniProtKB/TrEMBL

A0A8J1KPE7, A0A974CSQ1

Related

ENSXLAP00005083284.1, ENSXLAT00005084922.1

Conserved Domains (1) summary

COG5176
Location:108 → 246

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
XM_041562166.1 → XP_041418100.1 protein quaking-B isoform X1

UniProtKB/TrEMBL

A0A8J1KLB4, A0A974CSQ1

Conserved Domains (1) summary

COG5176
Location:108 → 246

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
XM_041562173.1 → XP_041418107.1 protein quaking-B isoform X8

UniProtKB/TrEMBL

A0A8J1KLA3, A0A974CSQ1

Related

ENSXLAP00005083554.1, ENSXLAT00005085192.1

Conserved Domains (1) summary

COG5176
Location:108 → 231

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
XM_041562171.1 → XP_041418105.1 protein quaking-B isoform X6

UniProtKB/TrEMBL

A0A8J1KLC1, A0A974CSQ1

Conserved Domains (2) summary

COG5176
Location:108 → 231

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]

PRK14950
Location:220 → 330

PRK14950; DNA polymerase III subunits gamma and tau; Provisional
XM_041562172.1 → XP_041418106.1 protein quaking-B isoform X7

UniProtKB/TrEMBL

A0A8J1KLB2, A0A974CSQ1

Related

ENSXLAP00005083497.1, ENSXLAT00005085135.1

Conserved Domains (1) summary

COG5176
Location:108 → 231

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]
XM_041562169.1 → XP_041418103.1 protein quaking-B isoform X4

UniProtKB/TrEMBL

A0A8J1KMZ9, A0A974CSQ1

Related

ENSXLAP00005083373.1, ENSXLAT00005085012.1

Conserved Domains (1) summary

COG5176
Location:108 → 231

MSL5; Splicing factor (branch point binding protein) [RNA processing and modification]