U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

otx2.L orthodenticle homeobox 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 432013, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
otx2.L
Official Full Name
orthodenticle homeobox 2 L homeolog
Primary source
Xenbase:XB-GENE-485224
Locus tag
XELAEV_18039840mg
See related
EnsemblRapid:ENSXLAG00005028155
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
otxA; Xotx2; otx-2; Xotx-2; otx2-a; otx2-b; otx2.S
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 8L
Exon count:
4
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (95776826..95783838)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (81096707..81103883)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 30, NatC catalytic subunit L homeolog Neighboring gene adaptor related protein complex 5 subunit mu 1 L homeolog Neighboring gene exocyst complex component 5 L homeolog Neighboring gene transmembrane protein 260 L homeolog Neighboring gene pellino E3 ubiquitin protein ligase family member 2 L homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Anterior neurectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle. Blitz IL, et al. Development, 1995 Apr. PMID 7743941
  2. Phosphorylation states change Otx2 activity for cell proliferation and patterning in the Xenopus embryo. Satou Y, et al. Development, 2018 Mar 12. PMID 29440302
  3. The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog. Juraver-Geslin HA, et al. Dev Biol, 2014 Dec 1. PMID 25281935
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Otx2 orchestrates cell proliferation, anteroposterior patterning and eye formation via its phosphorylation state.
    Title: Phosphorylation states change Otx2 activity for cell proliferation and patterning in the Xenopus embryo.
  2. barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog
    Title: The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC78801

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
homeobox protein OTX2-B
Names
orthodenticle 2-B
orthodenticle homeobox 2 S homeolog
orthodenticle-A-like protein B
xOTX2-B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001091486.1 → NP_001084955.1  homeobox protein OTX2-B

    See identical proteins and their annotated locations for NP_001084955.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070526
    UniProtKB/Swiss-Prot
    Q6DKN2
    UniProtKB/TrEMBL
    A0A974H8C1
    Related
    ENSXLAP00005083814.1, ENSXLAT00005085452.1
    Conserved Domains (2) summary
    pfam00046
    Location:42 → 94
    Homeobox; Homeobox domain
    pfam03529
    Location:153 → 234
    TF_Otx; Otx1 transcription factor

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    95776826..95783838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018228840.2 → XP_018084329.1  homeobox protein OTX2-B isoform X1

    UniProtKB/TrEMBL
    A0A8J0TI41
    Related
    ENSXLAP00005083842.1, ENSXLAT00005085480.1
    Conserved Domains (2) summary
    pfam00046
    Location:61 → 113
    Homeobox; Homeobox domain
    pfam03529
    Location:174 → 253
    TF_Otx; Otx1 transcription factor

  2. XM_041571994.1 → XP_041427928.1  homeobox protein OTX2-B isoform X1

    UniProtKB/TrEMBL
    A0A8J0TI41
    Conserved Domains (2) summary
    pfam00046
    Location:61 → 113
    Homeobox; Homeobox domain
    pfam03529
    Location:174 → 253
    TF_Otx; Otx1 transcription factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DKN2.1 GenPept UniProtKB/Swiss-Prot:Q6DKN2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials