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DCLRE1C DNA cross-link repair 1C [ Gallus gallus (chicken) ]

Gene ID: 430764, updated on 3-Apr-2024

Summary

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Symbol
DCLRE1Cprovided by CGNC
Full Name
DNA cross-link repair 1Cprovided by CGNC
Primary source
CGNC:10415
See related
Ensembl:ENSGALG00010006004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
SNM1C; artemis; nuclease
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (8049148..8059758, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (8166898..8177516, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene suppressor of variegation 3-9 homolog 2 Neighboring gene meiosis/spermiogenesis associated 1 Neighboring gene uncharacterized LOC121108083 Neighboring gene transmembrane protein 243

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Yosaatmadja Y, et al. Nucleic Acids Res, 2021 Sep 20. PMID 34387696, Free PMC Article
  2. KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation. Abe T, et al. Cell Signal, 2008 Nov. PMID 18674614
  3. DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation. Ishiai M, et al. Mol Cell Biol, 2004 Dec. PMID 15572677, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
    Title: Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
  2. KU70 and DNA-PKcs unexpectedly function together during the induction of apoptosis.
    Title: KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5'-3' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protection from non-homologous end joining at telomere IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein artemis
Names
DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)
DNA cross-link repair 1C protein
SNM1 homolog C
SNM1-like protein
chSNM1C
NP_001026765.2
XP_040557674.1
XP_046764561.1
XP_046764562.1
XP_046799133.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031594.2 → NP_001026765.2  protein artemis

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000011
    UniProtKB/TrEMBL
    A0A8V0XR57
    Related
    ENSGALP00010008421.1, ENSGALT00010014353.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    8049148..8059758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046943177.1 → XP_046799133.1  protein artemis isoform X2

  2. XM_040701740.2 → XP_040557674.1  protein artemis isoform X1

    UniProtKB/Swiss-Prot
    Q5QJC2
    Conserved Domains (1) summary
    cl23716
    Location:99 → 217
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    8166898..8177516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046908606.1 → XP_046764562.1  protein artemis isoform X2

  2. XM_046908605.1 → XP_046764561.1  protein artemis isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5QJC2.1 GenPept UniProtKB/Swiss-Prot:Q5QJC2

Gene LinkOut

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