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PQBP1 Poly-glutamine tract binding protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43004, updated on 10-May-2024

Summary

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Official Symbol
PQBP1provided by FlyBase
Official Full Name
Poly-glutamine tract binding protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0039270
Locus tag
Dmel_CG11820
See related
AllianceGenome:FB:FBgn0039270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11820; Dmel\CG11820; dPQBP-1; dpqbp1; dPQBP1; PQBP-1
Summary
Predicted to enable ribonucleoprotein complex binding activity. Involved in several processes, including microvillus organization; olfactory learning; and rhabdomere development. Located in nucleus and rough endoplasmic reticulum. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; extended germ band embryo; eye; and spermatozoon. Used to study Renpenning syndrome. Human ortholog(s) of this gene implicated in Renpenning syndrome. Orthologous to human PQBP1 (polyglutamine binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See PQBP1 in Genome Data Viewer
Location:
96B19-96B19; 3-86 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25065791..25066718)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20891513..20892440)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene staccato Neighboring gene veli Neighboring gene Catalytic subunit 3B of the oligosaccharyltransferase complex Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship. Yoshimura N, et al. FEBS Lett, 2006 Apr 17. PMID 16597440
  2. A restricted level of PQBP1 is needed for the best longevity of Drosophila. Tamura T, et al. Neurobiol Aging, 2013 Jan. PMID 22901698
  3. Mutations of PQBP1 in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction. Zhang XY, et al. Hum Mol Genet, 2017 Mar 1. PMID 28073926
  4. Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning. Tamura T, et al. J Neurosci, 2010 Oct 20. PMID 20962230, Free PMC Article
  5. Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster. LaFerriere H, et al. Genetics, 2008 Apr. PMID 18430923, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in microvillus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rhabdomere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Poly-glutamine tract binding protein 1
Names
CG11820-PA
PQBP1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25065791..25066718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143074.4 → NP_651331.1  Poly-glutamine tract binding protein 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651331.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VBY6
    Related
    FBpp0084140
    Conserved Domains (1) summary
    pfam00397
    Location:130 → 160
    WW; WW domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VBY6 Q9VBY6

Gene LinkOut

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