stac staccato [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: stacprovided by FlyBase
Official Full Name: staccatoprovided by FlyBase
Primary source: FLYBASE:FBgn0266719
Locus tag: Dmel_CG34349
See related: AllianceGenome:FB:FBgn0266719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BP1013; CG11819; CG34037; CG34349; Dmel\CG34349; dunc-13-4B; Stac; unc-13-4B; Unc-13-4B
Old locus tag: CG11819; CG34037; Dmel_CG11819; Dmel_CG34037
Summary: Involved in branch fusion, open tracheal system. Located in secretory vesicle. Is expressed in adult head; embryonic/larval circulatory system; embryonic/larval hindgut; embryonic/larval muscle system; and epithelium. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 3. Orthologous to human BAIAP3 (BAI1 associated protein 3) and UNC13D (unc-13 homolog D). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 96B19-96B19; 3-86 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25056286..25064348)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20882008..20890070)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GTPase Arl3 is necessary and sufficient for Stac lysosome-related organelle formation and promotes Stac-dependent intracellular fusion of juxtaposed apical plasma membranes
Title: Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic vesicle priming	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in secretory vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: staccato

Names: CG34349-PC; CG34349-PD; CG34349-PE; Unc-13 ortholog 4B; Uncoordinated-13 4B; stac-PC; stac-PD; stac-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25056286..25064348

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276018.1 → NP_001262947.1 staccato, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262947.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VBY8

Conserved Domains (3) summary

cd04009
Location:980 → 1106

C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins

pfam10540
Location:865 → 961

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cl14603
Location:142 → 307

C2; C2 domain
NM_143072.4 → NP_651329.4 staccato, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651329.4

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4KHI5, A8JRA6, B3DN10, C6SV37, Q9VBY8

Conserved Domains (3) summary

cd04009
Location:990 → 1116

C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins

pfam10540
Location:875 → 971

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cl14603
Location:152 → 317

C2; C2 domain
NM_001104439.3 → NP_001097909.2 staccato, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097909.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VBY8

Conserved Domains (3) summary

cd04009
Location:965 → 1091

C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins

pfam10540
Location:850 → 946

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

cl14603
Location:127 → 292

C2; C2 domain