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CG4390 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42396, updated on 18-Sep-2024

Summary

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Official Symbol
CG4390provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038771
Locus tag
Dmel_CG4390
See related
AllianceGenome:FB:FBgn0038771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4390
Summary
Enables serine hydrolase activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be active in cytosol. Is expressed in organism. Orthologous to human ESD (esterase D). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
92C4-92C4; 3-67 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20056418..20059750, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15882140..15885472, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Regnase 1 Neighboring gene identity crisis Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene I'm not dead yet 2 Neighboring gene midlife crisis Neighboring gene Rhodopsin 3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-Wide Association Analyses Point to Candidate Genes for Electric Shock Avoidance in Drosophila melanogaster. Appel M, et al. PLoS One, 2015. PMID 25992709, Free PMC Article
  2. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
  3. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
  4. SUMO-Enriched Proteome for Drosophila Innate Immune Response. Handu M, et al. G3 (Bethesda), 2015 Aug 18. PMID 26290570, Free PMC Article
  5. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables S-formylglutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-formylglutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine hydrolase activity HDA PubMed 
Process Evidence Code Pubs
involved_in formaldehyde catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4390-PA
CG4390-PB
NP_650864.1
NP_732486.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20056418..20059750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169887.2 → NP_732486.2  uncharacterized protein Dmel_CG4390, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732486.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SUZ3, Q7KSB5
    Related
    FBpp0083245
    Conserved Domains (2) summary
    COG0627
    Location:45 → 330
    FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]
    cl21494
    Location:48 → 326
    Abhydrolase; alpha/beta hydrolases

  2. NM_142607.2 → NP_650864.1  uncharacterized protein Dmel_CG4390, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650864.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SUZ3, Q9VDP9
    Related
    FBpp0083246
    Conserved Domains (2) summary
    COG0627
    Location:1 → 286
    FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]
    cl21494
    Location:4 → 282
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KSB5 Q7KSB5
Q9VDP9 Q9VDP9

Gene LinkOut

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