U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

psidin phagocyte signaling impaired [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42389, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
psidinprovided by FlyBase
Official Full Name
phagocyte signaling impairedprovided by FlyBase
Primary source
FLYBASE:FBgn0243511
Locus tag
Dmel_CG4845
See related
AllianceGenome:FB:FBgn0243511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4845; Dmel\CG4845; dNAA25; ird16; Naa25; psid; psif
Summary
Enables actin filament binding activity. Involved in several processes, including border follicle cell migration; positive regulation of lamellipodium assembly; and sensory neuron axon guidance. Located in growth cone lamellipodium and lysosome. Part of NatB complex. Is expressed in brain; egg chamber; eye-antennal disc; head; and spermatozoon. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
92C1-92C1; 3-67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20021704..20026482)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15847426..15852204)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class L Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene trade embargo

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Maturation of NAA20 Aminoterminal End Is Essential to Assemble NatB N-Terminal Acetyltransferase Complex. Lasa M, et al. J Mol Biol, 2020 Nov 6. PMID 32976911
  2. Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms. Stephan D, et al. J Neurosci, 2012 Nov 14. PMID 23152593, Free PMC Article
  3. Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body. Brennan CA, et al. Curr Biol, 2007 Jan 9. PMID 17208189
  4. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Kim JH, et al. Genes Dev, 2011 Apr 1. PMID 21406550, Free PMC Article
  5. Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response. Charroux B, et al. Proc Natl Acad Sci U S A, 2009 Jun 16. PMID 19482944, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways.
    Title: NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways.
  2. Psidin plays two independent developmental roles via the acquisition of separate signaling pathways, both of which contribute to the formation of olfactory circuits
    Title: Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms.
  3. Psid is an actin regulatory protein that plays a conserved role in protrusion dynamics and cell migration.
    Title: Psidin, a conserved protein that regulates protrusion dynamics and cell migration.
  4. encodes a lysosomal protein required in the blood cells for both degradation of engulfed bacteria and activation of fat-body Defensin
    Title: Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament depolymerization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in activation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NatB complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatB complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
phagocyte signaling impaired
Names
CG4845-PA
N(alpha)-acetyltransferase 25
immune response deficient 16
psidin-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20021704..20026482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142601.2 → NP_650858.1  phagocyte signaling impaired [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650858.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YTX6, Q9VDQ7
    UniProtKB/TrEMBL
    U3Q053
    Related
    FBpp0083238
    Conserved Domains (3) summary
    sd00006
    Location:48 → 74
    TPR; TPR repeat [structural motif]
    pfam09797
    Location:264 → 642
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit
    pfam13424
    Location:42 → 108
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VDQ7.1 Q9VDQ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools