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WHSC1 Wolf-Hirschhorn syndrome candidate 1 [ Gallus gallus (chicken) ]

Gene ID: 422897, updated on 5-Mar-2024

Summary

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Symbol
WHSC1provided by CGNC
Full Name
Wolf-Hirschhorn syndrome candidate 1provided by CGNC
Primary source
CGNC:11713
See related
Ensembl:ENSGALG00010016910
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
NSD2
Orthologs
human mouse all
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Genomic context

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See WHSC1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
29
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (82724411..82826708, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (82702702..82805061, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member A Neighboring gene small Cajal body-specific RNA 23 Neighboring gene down-regulated in colon cancer 1 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene ADP/ATP translocase 4-like Neighboring gene fibroblast growth factor receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K36 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase NSD2
Names
Wolf-Hirschhorn syndrome candidate 1 protein
nuclear receptor binding SET domain protein 2
XP_015141481.2
XP_015141482.2
XP_015141484.2
XP_015141485.2
XP_015141486.2
XP_015141487.2
XP_015141491.2
XP_015141492.2
XP_015141495.2
XP_040525801.1
XP_040525802.1
XP_040525803.1
XP_040525804.1
XP_040525806.1
XP_040525808.1
XP_040525810.1
XP_040525811.1
XP_040525812.1
XP_046772696.1
XP_046796405.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    82724411..82826708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015286001.4 → XP_015141487.2  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z049
    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  2. XM_015286006.4 → XP_015141492.2  histone-lysine N-methyltransferase NSD2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YYB7
    Related
    ENSGALP00010023781.1, ENSGALT00010040817.1
    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:840 → 934
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:974 → 1024
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:678 → 724
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:725 → 778
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:795 → 835
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1203 → 1245
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1024 → 1165
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:631 → 673
    PHD_SF; PHD finger superfamily

  3. XM_015286005.4 → XP_015141491.2  histone-lysine N-methyltransferase NSD2 isoform X2

    Conserved Domains (8) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:849 → 943
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:983 → 1033
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1212 → 1254
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1033 → 1174
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:809 → 844
    PHD_SF; PHD finger superfamily

  4. XM_015285995.4 → XP_015141481.2  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z049
    Related
    ENSGALP00010023777.1, ENSGALT00010040813.1
    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  5. XM_015285999.4 → XP_015141485.2  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z049
    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  6. XM_015286000.4 → XP_015141486.2  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z049
    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  7. XM_015285996.4 → XP_015141482.2  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z049
    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  8. XM_015285998.4 → XP_015141484.2  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z049
    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  9. XM_046940449.1 → XP_046796405.1  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z049

  10. XM_015286009.4 → XP_015141495.2  histone-lysine N-methyltransferase NSD2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z044, A0A8V0Z5I1
    Related
    ENSGALP00010023775.1, ENSGALT00010040811.1
    Conserved Domains (2) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    82702702..82805061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040669869.2 → XP_040525803.1  histone-lysine N-methyltransferase NSD2 isoform X1

    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  2. XM_040669877.2 → XP_040525811.1  histone-lysine N-methyltransferase NSD2 isoform X3

    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:840 → 934
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:974 → 1024
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:678 → 724
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:725 → 778
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:795 → 835
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1203 → 1245
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1024 → 1165
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:631 → 673
    PHD_SF; PHD finger superfamily

  3. XM_040669876.2 → XP_040525810.1  histone-lysine N-methyltransferase NSD2 isoform X2

    Conserved Domains (8) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:849 → 943
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:983 → 1033
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1212 → 1254
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1033 → 1174
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:809 → 844
    PHD_SF; PHD finger superfamily

  4. XM_040669867.2 → XP_040525801.1  histone-lysine N-methyltransferase NSD2 isoform X1

    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  5. XM_040669870.2 → XP_040525804.1  histone-lysine N-methyltransferase NSD2 isoform X1

    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  6. XM_040669874.2 → XP_040525808.1  histone-lysine N-methyltransferase NSD2 isoform X1

    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  7. XM_040669868.2 → XP_040525802.1  histone-lysine N-methyltransferase NSD2 isoform X1

    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  8. XM_040669872.2 → XP_040525806.1  histone-lysine N-methyltransferase NSD2 isoform X1

    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:909 → 1003
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1043 → 1093
    AWS; associated with SET domains
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:747 → 793
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:794 → 847
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:864 → 904
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1272 → 1314
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1093 → 1234
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    cl22851
    Location:700 → 742
    PHD_SF; PHD finger superfamily

  9. XM_046916740.1 → XP_046772696.1  histone-lysine N-methyltransferase NSD2 isoform X1

  10. XM_040669878.2 → XP_040525812.1  histone-lysine N-methyltransferase NSD2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z044
    Conserved Domains (2) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd00084
    Location:463 → 512
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
Nucleotide Protein Strain
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