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P5cr Pyrroline 5-carboyxlate reductase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42284, updated on 10-May-2024

Summary

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Official Symbol
P5crprovided by FlyBase
Official Full Name
Pyrroline 5-carboyxlate reductaseprovided by FlyBase
Primary source
FLYBASE:FBgn0015781
Locus tag
Dmel_CG6009
See related
AllianceGenome:FB:FBgn0015781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6009; Dmel\CG6009; P5CR
Summary
Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Is expressed in adult head; embryonic/larval garland cell; and organism. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
91E4-91E4; 3-65 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19028931..19030159)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14854653..14855881)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glutamyl-tRNA amidotransferase, subunit A Neighboring gene NP15.6 Neighboring gene Prp18 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complementation cloning and characterization of the pyrroline 5-carboxylate reductase gene from Drosophila melanogaster. Misener SR, et al. Biochem Genet, 2001 Feb. PMID 11444018
  2. Cold tolerance and proline metabolic gene expression in Drosophila melanogaster. Misener SR, et al. J Insect Physiol, 2001 Apr. PMID 11166304
  3. Extraordinarily high density of unrelated genes showing overlapping and intraintronic transcription units. Misener SR, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 10858562
  4. Mutations in the Drosophila mitochondrial tRNA amidotransferase, bene/gatA, cause growth defects in mitotic and endoreplicating tissues. Morris JZ, et al. Genetics, 2008 Feb. PMID 18245325, Free PMC Article
  5. Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4. Baltzer C, et al. PLoS One, 2009 Sep 9. PMID 19742324, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrroline-5-carboxylate reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyrroline 5-carboyxlate reductase
Names
CG6009-PA
P5cr-PA
pyrroline 5-carboxylate
reductase
NP_524400.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19028931..19030159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079676.4 → NP_524400.2  pyrroline 5-carboyxlate reductase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524400.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96643, Q9V3F8
    Related
    FBpp0083127
    Conserved Domains (3) summary
    COG0345
    Location:6 → 280
    ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
    pfam03807
    Location:9 → 106
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    pfam14748
    Location:172 → 276
    P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O96643 O96643
Q9V3F8 Q9V3F8

Gene LinkOut

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