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Xrp1 Xrp1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42267, updated on 18-Sep-2024

Summary

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Official Symbol
Xrp1provided by FlyBase
Official Full Name
Xrp1provided by FlyBase
Primary source
FLYBASE:FBgn0261113
Locus tag
Dmel_CG17836
See related
AllianceGenome:FB:FBgn0261113
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2515; anon-EST:Liang-2.44; CG17836; clone 2.44; DM28; Dmel\CG17836; l(3)02515; Xrp; xrp1; XRP1
Summary
Enables P-element binding activity and chromatin binding activity. Involved in chromosome organization; double-strand break repair; and negative regulation of cell population proliferation. Located in nucleus. Part of DNA repair complex. Is expressed in several structures, including embryonic epidermis; embryonic/larval posterior spiracle; and extended germ band embryo. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
91D4-91D5; 3-65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18914968..18926989)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14740690..14752711)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Endophilin A Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene uncharacterized protein Neighboring gene Mitochondrial pyruvate carrier Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis. Francis MJ, et al. Proc Natl Acad Sci U S A, 2016 Nov 15. PMID 27799520, Free PMC Article
  2. Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster. Lee CH, et al. G3 (Bethesda), 2016 Oct 13. PMID 27574103, Free PMC Article
  3. Reducing the aneuploid cell burden - cell competition and the ribosome connection. Baker NE, et al. Dis Model Mech, 2022 Nov 1. PMID 36444717, Free PMC Article
  4. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α. Ochi N, et al. PLoS Genet, 2021 Dec. PMID 34871307, Free PMC Article
  5. Distinct p53 isoforms code for opposing transcriptional outcomes. Wylie A, et al. Dev Cell, 2022 Aug 8. PMID 35820415, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Xrp1 governs the stress response program to spliceosome dysfunction.
    Title: Xrp1 governs the stress response program to spliceosome dysfunction.
  2. Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status.
    Title: Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status.
  3. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2alpha.
    Title: Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α.
  4. The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila.
    Title: The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila.
  5. Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila.
    Title: Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila.
  6. Findings provide clear molecular and genetic evidence that RpS12 plays a central and early role in generating multiple aspects of the Ribosomal Protein (Rp)+/- phenotype in imaginal discs by activating Xrp1 expression and activity.
    Title: Drosophila RpS12 controls translation, growth, and cell competition through Xrp1.
  7. demonstrates that RpS12, Xrp1, and Dilp8 form an independent regulatory module that ensures intra- and inter-organ growth coordination during development
    Title: Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila.
  8. Xrp1 knockdown substantially rescued the motor deficits and life span of flies expressing ALS mutant FUS in motor neurons, implicating gene expression dysregulation in ALS-FUS pathogenesis.
    Title: Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity.
  9. Xrp1 induction in Rp mutant cells depends on a particular Rp with regulatory effects
    Title: A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition.
  10. CG17836/Xrp1 is involved in the regulation of cell proliferation in eye discs and affects disc identity specification.
    Title: Ectopic antenna induction by overexpression of CG17836/Xrp1 encoding an AT-hook DNA binding motif protein in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 18917445-18917825 mobile_element_type = transposon:S2{}1385
  • Loc: 18922054-18922275 mobile_element_type = transposon:1360{}4814

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables P-element binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA repair complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Xrp1
Names
CG17836-PA
CG17836-PB
CG17836-PC
CG17836-PD
CG17836-PE
CG17836-PF
CG17836-PG
Xrp1-PA
Xrp1-PB
Xrp1-PC
Xrp1-PD
Xrp1-PE
Xrp1-PF
Xrp1-PG
lethal (3) 02515

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18914968..18926989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142504.4 → NP_650761.2  Xrp1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650761.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VE23
    Related
    FBpp0083114
    Conserved Domains (1) summary
    cd14686
    Location:599 → 640
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  2. NM_001275790.1 → NP_001262719.1  Xrp1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262719.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VE23
    Conserved Domains (1) summary
    cd14686
    Location:599 → 640
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  3. NM_169839.3 → NP_732384.1  Xrp1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VE23
    Related
    FBpp0083115
    Conserved Domains (1) summary
    cd14686
    Location:599 → 640
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  4. NM_169840.3 → NP_732385.1  Xrp1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732385.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I0S0, Q8IN74
    Related
    FBpp0083116
    Conserved Domains (1) summary
    cd14686
    Location:337 → 378
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  5. NM_001104363.2 → NP_001097833.1  Xrp1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097833.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I0S0, Q8IN74
    Conserved Domains (1) summary
    cd14686
    Location:337 → 378
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  6. NM_001275789.1 → NP_001262718.1  Xrp1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262718.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VE23
    Conserved Domains (1) summary
    cd14686
    Location:599 → 640
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

  7. NM_169841.2 → NP_732386.1  Xrp1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732386.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I0S0, Q8IN74
    Related
    FBpp0083117
    Conserved Domains (1) summary
    cd14686
    Location:337 → 378
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8I0S0 Q8I0S0
Q8IN74 Q8IN74
Q8T9G5 Q8T9G5
Q9VE23 Q9VE23

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