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Pxt Peroxinectin-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42131, updated on 10-May-2024

Summary

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Official Symbol
Pxtprovided by FlyBase
Official Full Name
Peroxinectin-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0261987
Locus tag
Dmel_CG7660
See related
AllianceGenome:FB:FBgn0261987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0172774.128; CG7660; Dmel\CG7660; Dpxt; pxd; pxt
Summary
Predicted to enable peroxidase activity. Involved in chorion-containing eggshell formation and prostaglandin biosynthetic process. Located in extracellular space. Is expressed in several structures, including adult head; germline cell; and ovariole. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Pxt in Genome Data Viewer
Location:
90C2-90C2; 3-61 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17719454..17722955)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13545176..13548677)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene osa Neighboring gene long non-coding RNA:CR46036 Neighboring gene long non-coding RNA:CR46035 Neighboring gene Autophagy-related 8b Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Fascin is a novel downstream target of prostaglandin signaling during actin remodeling. Groen CM, et al. Mol Biol Cell, 2012 Dec. PMID 23051736, Free PMC Article
  2. Prostaglandins limit nuclear actin to control nucleolar function during oogenesis. Talbot DE, et al. Front Cell Dev Biol, 2023. PMID 36875757, Free PMC Article
  3. What is in a model? Kang DS, et al. Arch Insect Biochem Physiol, 2023 Jan. PMID 36164283
  4. Prostaglandins regulate invasive, collective border cell migration. Fox EF, et al. Mol Biol Cell, 2020 Jul 15. PMID 32432969, Free PMC Article
  5. Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation. Tootle TL, et al. Development, 2008 Mar. PMID 18216169, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in pxt, encoding a putative Drosophila cyclooxygenase, cause many transcripts to begin expression prematurely, and are associated with eggshell defects.
    Title: Drosophila eggshell production: identification of new genes and coordination by Pxt.
  2. Drosophila ovarian follicle maturation requires cyclooxygenase-like activity, supplied by peroxidase PXT.
    Title: Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation.
  3. Dpxt function is restricted to the early stages of fly development
    Title: A new peroxinectin-like gene preferentially expressed during oogenesis and early embryogenesis in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chorion-containing eggshell formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg chorion assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in follicle cell of egg chamber development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hydrogen peroxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Peroxinectin-like
Names
CG7660-PB
Pxt-PB
pxd
pxt
NP_650648.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17719454..17722955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142391.5 → NP_650648.3  Peroxinectin-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650648.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN93, Q8MRH7, Q9NBX0, Q9VEG6
    Related
    FBpp0082932
    Conserved Domains (3) summary
    cd09823
    Location:396 → 767
    peroxinectin_like; peroxinectin_like animal heme peroxidases
    pfam03098
    Location:237 → 772
    An_peroxidase; Animal haem peroxidase
    cl02511
    Location:67 → 119
    GH64-TLP-SF; glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEG6.3 Q9VEG6

Gene LinkOut

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