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Sb Stubble [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41958, updated on 10-May-2024

Summary

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Official Symbol
Sbprovided by FlyBase
Official Full Name
Stubbleprovided by FlyBase
Primary source
FLYBASE:FBgn0003319
Locus tag
Dmel_CG4316
See related
AllianceGenome:FB:FBgn0003319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c-SP56; CG4316; cSP56; Dmel\CG4316; Sb-sbd; sbd; SP56; st-sb
Summary
Predicted to enable serine-type endopeptidase activity. Involved in actin filament bundle assembly and wing disc development. Predicted to be located in plasma membrane. Is expressed in imaginal disc; leg; wing; wing anterior compartment; and wing pouch. Orthologous to human TMPRSS13 (transmembrane serine protease 13) and TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
89B4-89B6; 3-58 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16116161..16145284)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11941883..11971006)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Myosin heavy chain-like Neighboring gene sex-specific enzyme 2 Neighboring gene Akt kinase Neighboring gene MICOS subunit 26/27 Neighboring gene uncharacterized protein Neighboring gene 48 related 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43472

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Persistence of a mutant gene in Drosophila populations of different genetic backgrounds. Chung YJ. Genetics, 1967 Dec. PMID 17248400, Free PMC Article
  2. Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. Hooper JD, et al. J Biol Chem, 2001 Jan 12. PMID 11060317
  3. The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis. Appel LF, et al. Proc Natl Acad Sci U S A, 1993 Jun 1. PMID 7685111, Free PMC Article
  4. Apical cell shape changes during Drosophila imaginal leg disc elongation: a novel morphogenetic mechanism. Condic ML, et al. Development, 1991 Jan. PMID 2015798
  5. Orphan nuclear receptor betaFTZ-F1 is required for muscle-driven morphogenetic events at the prepupal-pupal transition in Drosophila melanogaster. Fortier TM, et al. Dev Biol, 2003 May 1. PMID 12710964

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Helps coordinate proteolytic modification of extracellular matrix attachments with cytoskeletal changes in both legs and bristles.
    Title: Mutational analysis of Stubble-stubbloid gene structure and function in Drosophila leg and bristle morphogenesis.
  2. RhoA and Sb-sbd act in a common pathway during leg morphogenesis
    Title: Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
stubble
Names
CG4316-PA
CG4316-PB
Sb-PA
Sb-PB
Stubble-stubbloid
stubbloid
NP_001287355.1
NP_476709.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16116161..16145284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300426.1 → NP_001287355.1  stubble, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287355.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05319, Q8MRH5, Q9VEY6
    UniProtKB/TrEMBL
    A0A0B4LH73
    Conserved Domains (2) summary
    smart00020
    Location:543 → 782
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:544 → 785
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_057361.4 → NP_476709.1  stubble, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476709.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05319, Q8MRH5, Q9VEY6
    UniProtKB/TrEMBL
    A0A0B4LH73
    Related
    FBpp0082704
    Conserved Domains (2) summary
    smart00020
    Location:543 → 782
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:544 → 785
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LH73 A0A0B4LH73
Q05319.2 Q05319

Gene LinkOut

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