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140up upstream of RpII140 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41720, updated on 18-Sep-2024

Summary

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Official Symbol
140upprovided by FlyBase
Official Full Name
upstream of RpII140provided by FlyBase
Primary source
FLYBASE:FBgn0010340
Locus tag
Dmel_CG9852
See related
AllianceGenome:FB:FBgn0010340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9852; Dmel\CG9852; DmRP140-upstream; DmRP140up; dTIMMDC1; l(3)88Ba; l(3)Z6
Summary
Predicted to be active in mitochondrion. Is expressed in adult head; embryonic/larval midgut; embryonic/larval visceral muscle cell; and organism. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 31. Orthologous to human TIMMDC1 (translocase of inner mitochondrial membrane domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
88A9-88A9; 3-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14124163..14125548, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9949885..9951270, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Kinesin family member 19A Neighboring gene Abelson interacting protein Neighboring gene twinfilin Neighboring gene RNA polymerase II subunit B Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription of DmRP140, the gene coding for the second-largest subunit of RNA polymerase II. Wiedemann M, et al. Biochim Biophys Acta, 1997 Feb 28. PMID 9061024
  2. Twinfilin is required for actin-dependent developmental processes in Drosophila. Wahlström G, et al. J Cell Biol, 2001 Nov 26. PMID 11724820, Free PMC Article
  3. Analysis of the promoter region of the housekeeping gene DmRP140 by sequence comparison of Drosophila melanogaster and Drosophila virilis. Sitzler S, et al. Gene, 1991 Apr. PMID 1905256
  4. Reverse genetics of Drosophila RNA polymerase II: identification and characterization of RpII140, the genomic locus for the second-largest subunit. Hamilton BJ, et al. Genetics, 1993 Jun. PMID 8325487, Free PMC Article
  5. Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila. Breen TR, et al. Mech Dev, 1991 Sep. PMID 1684714

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
upstream of RpII140
Names
140up-PA
140up-PB
CG9852-PA
CG9852-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14124163..14125548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275632.1 → NP_001262561.1  upstream of RpII140, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262561.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P81928, Q9VFM8
    UniProtKB/TrEMBL
    A0A0B4KFZ0
    Conserved Domains (1) summary
    pfam02466
    Location:67 → 179
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  2. NM_057603.6 → NP_476951.1  upstream of RpII140, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476951.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P81928, Q9VFM8
    UniProtKB/TrEMBL
    A0A0B4KFZ0
    Related
    FBpp0082370
    Conserved Domains (1) summary
    pfam02466
    Location:67 → 179
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFZ0 A0A0B4KFZ0
P81928.2 P81928

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