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GCC185 GRIP and coiled-coil domain containing 185 kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41459, updated on 10-May-2024

Summary

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Official Symbol
GCC185provided by FlyBase
Official Full Name
GRIP and coiled-coil domain containing 185 kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0037979
Locus tag
Dmel_CG3532
See related
AllianceGenome:FB:FBgn0037979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3532; dGCC185; Dmel\CG3532
Summary
Enables small GTPase binding activity. Predicted to be involved in protein localization to Golgi apparatus and retrograde transport, endosome to Golgi. Located in Golgi trans cisterna. Is expressed in adult head and spermatozoon. Orthologous to human GCC2 (GRIP and coiled-coil domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See GCC185 in Genome Data Viewer
Location:
87A5-87A5; 3-51 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12010772..12015059)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7836494..7840781)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tachykinin Neighboring gene Ectoderm-expressed 3 Neighboring gene Kelch like family member 18 Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene Spt3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development. Maccallini P, et al. PLoS Genet, 2020 May. PMID 32453722, Free PMC Article
  2. bicoid RNA localization requires the trans-Golgi network. Cai X, et al. Hereditas, 2019. PMID 31528161, Free PMC Article
  3. The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila. Torres IL, et al. J Cell Sci, 2014 May 15. PMID 24610947, Free PMC Article
  4. A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation. Zacharogianni M, et al. Elife, 2014 Nov 11. PMID 25386913, Free PMC Article
  5. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi vesicle transport IC
Inferred by Curator
more info
 PubMed 
involved_in protein localization to Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GRIP and coiled-coil domain containing 185 kDa
Names
CG3532-PB
GCC185 ortholog
GCC185-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12010772..12015059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104285.2 → NP_001097755.1  GRIP and coiled-coil domain containing 185 kDa [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097755.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q32KE8, Q9VGE4
    Conserved Domains (3) summary
    TIGR02168
    Location:35 → 813
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01465
    Location:1058 → 1100
    GRIP; GRIP domain
    pfam07851
    Location:458 → 548
    TMPIT; TMPIT-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGE4 Q9VGE4

Gene LinkOut

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