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Rfx [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41266, updated on 10-May-2024

Summary

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Official Symbol
Rfxprovided by FlyBase
Primary source
FLYBASE:FBgn0020379
Locus tag
Dmel_CG6312
See related
AllianceGenome:FB:FBgn0020379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6312; Dmel\CG6312; dRfx; dRFX; rfx; RFX
Summary
Enables sequence-specific DNA binding activity. Involved in nervous system development and sensory perception of sound. Is expressed in several structures, including anterior-posterior subdivision of organism; chordotonal neurons; dorsal closure embryo; presumptive embryonic/larval nervous system; and sensory mother cell. Orthologous to human RFX1 (regulatory factor X1); RFX2 (regulatory factor X2); and RFX3 (regulatory factor X3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Rfx in Genome Data Viewer
Location:
86B1-86B2; 3-49 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10361760..10378068, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6187482..6203790, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene jumeau Neighboring gene long non-coding RNA:CR44938 Neighboring gene clockwork orange

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila regulatory factor X is an embryonic type I sensory neuron marker also expressed in spermatids and in the brain of Drosophila. Vandaele C, et al. Mech Dev, 2001 May. PMID 11335126
  2. hemingway is required for sperm flagella assembly and ciliary motility in Drosophila. Soulavie F, et al. Mol Biol Cell, 2014 Apr. PMID 24554765, Free PMC Article
  3. Cloning and characterization of dRFX, the Drosophila member of the RFX family of transcription factors. Durand B, et al. Gene, 2000 Apr 4. PMID 10767550
  4. Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia. Moore DJ, et al. Am J Hum Genet, 2013 Aug 8. PMID 23891471, Free PMC Article
  5. Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation. Dubruille R, et al. Development, 2002 Dec. PMID 12403718

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It was shown that fd3F is required for specialization of the mechanosensory cilium of chordotonal neurons. Fd3F cooperates with the panciliary transcription factor, Rfx, to regulate its targets directly.
    Title: Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization.
  2. an essential regulator of ciliated sensory neuron differentiation in Drosophila
    Title: Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dendrite morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Rfx
Names
CG6312-PC
CG6312-PF
CG6312-PG
CG6312-PH
CG6312-PI
CG6312-PJ
Rfx-PC
Rfx-PF
Rfx-PG
Rfx-PH
Rfx-PI
Rfx-PJ
regulatory factor X

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10361760..10378068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260092.2 → NP_001247021.1  Rfx, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247021.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6P1, Q9U1K2
    Conserved Domains (1) summary
    pfam02257
    Location:385 → 458
    RFX_DNA_binding; RFX DNA-binding domain

  2. NM_141742.3 → NP_649999.2  Rfx, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649999.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1K2, Q9VGZ6
    Related
    FBpp0308021
    Conserved Domains (1) summary
    pfam02257
    Location:371 → 444
    RFX_DNA_binding; RFX DNA-binding domain

  3. NM_001260094.2 → NP_001247023.2  Rfx, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247023.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K653, Q9U1K2
    Conserved Domains (1) summary
    pfam02257
    Location:393 → 466
    RFX_DNA_binding; RFX DNA-binding domain

  4. NM_001275535.1 → NP_001262464.1  Rfx, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262464.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFL4
    Conserved Domains (1) summary
    pfam02257
    Location:356 → 429
    RFX_DNA_binding; RFX DNA-binding domain

  5. NM_001104268.2 → NP_001097738.2  Rfx, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097738.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JQX0, Q9U1K2
    Conserved Domains (1) summary
    pfam02257
    Location:363 → 436
    RFX_DNA_binding; RFX DNA-binding domain

  6. NM_001260093.2 → NP_001247022.2  Rfx, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247022.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K621
    Conserved Domains (1) summary
    pfam02257
    Location:334 → 407
    RFX_DNA_binding; RFX DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K621 A0A0B4K621
A0A0B4K653 A0A0B4K653
A0A0B4K6P1 A0A0B4K6P1
A0A0B4KFL4 A0A0B4KFL4
A8JQX0 A8JQX0
Q9U1K2 Q9U1K2
Q9VGZ6 Q9VGZ6

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