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CG42795 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41252, updated on 18-Sep-2024

Summary

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Official Symbol
CG42795provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0261928
Locus tag
Dmel_CG42795
See related
AllianceGenome:FB:FBgn0261928
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12816; CG34108; CG3996; Dmel\CG42795
Old locus tag
Dmel_CG34108; Dmel_CG3996
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of GTPase activity. Is expressed in adult head. Orthologous to human TBC1D30 (TBC1 domain family member 30). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
86A1-86A2; 3-49 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10225690..10251277)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6051412..6076999)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sirtuin 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of EMS-induced mutations in Drosophila melanogaster by whole-genome sequencing. Blumenstiel JP, et al. Genetics, 2009 May. PMID 19307605, Free PMC Article
  2. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
  3. Paternal diet affects differential gene expression, but not sperm competition, in sons. Zajitschek F, et al. Biol Lett, 2017 Feb. PMID 28202685, Free PMC Article
  4. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article
  5. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Bernards A. Biochim Biophys Acta, 2003 Mar 17. PMID 12618308

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42795-PA
CG42795-PB
CG42795-PC
CG42795-PE
CG42795-PF
CG42795-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10225690..10251277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300342.1 → NP_001287271.1  uncharacterized protein Dmel_CG42795, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LH38
    Conserved Domains (4) summary
    PTZ00121
    Location:1112 → 2009
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:2270 → 2610
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00566
    Location:224 → 443
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam15733
    Location:560 → 689
    DUF4682; Domain of unknown function (DUF4682)

  2. NM_001275526.2 → NP_001262455.1  uncharacterized protein Dmel_CG42795, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262455.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG40
    Conserved Domains (4) summary
    pfam00566
    Location:268 → 443
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12361
    Location:1112 → 1415
    DBP; Duffy-antigen binding protein
    pfam15733
    Location:560 → 684
    DUF4682; Domain of unknown function (DUF4682)
    pfam16496
    Location:2376 → 2482
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal

  3. NM_001300343.1 → NP_001287272.1  uncharacterized protein Dmel_CG42795, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287272.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LH08
    Conserved Domains (4) summary
    PTZ00121
    Location:1112 → 2009
    PTZ00121; MAEBL; Provisional
    PTZ00449
    Location:2270 → 2610
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00566
    Location:224 → 443
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam15733
    Location:560 → 689
    DUF4682; Domain of unknown function (DUF4682)

  4. NM_001300341.1 → NP_001287270.1  uncharacterized protein Dmel_CG42795, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287270.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGZ2
    Conserved Domains (4) summary
    pfam00566
    Location:268 → 443
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12361
    Location:1112 → 1415
    DBP; Duffy-antigen binding protein
    pfam15733
    Location:560 → 684
    DUF4682; Domain of unknown function (DUF4682)
    pfam16496
    Location:2376 → 2482
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal

  5. NM_001202279.2 → NP_001189208.1  uncharacterized protein Dmel_CG42795, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JCW7
    Conserved Domains (4) summary
    pfam00566
    Location:268 → 443
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam12361
    Location:1112 → 1415
    DBP; Duffy-antigen binding protein
    pfam15733
    Location:560 → 684
    DUF4682; Domain of unknown function (DUF4682)
    pfam16496
    Location:2376 → 2482
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal

  6. NM_141731.3 → NP_649988.2  uncharacterized protein Dmel_CG42795, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649988.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VH10
    Conserved Domains (3) summary
    pfam00566
    Location:147 → 322
    RabGAP-TBC; Rab-GTPase-TBC domain
    pfam15733
    Location:439 → 563
    DUF4682; Domain of unknown function (DUF4682)
    pfam16496
    Location:2255 → 2361
    SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JCW7 A0A0B4JCW7
A0A0B4KG40 A0A0B4KG40
A0A0B4LGZ2 A0A0B4LGZ2
A0A0B4LH08 A0A0B4LH08
A0A0B4LH38 A0A0B4LH38
Q9VH10 Q9VH10

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