5-HT2B 5-hydroxytryptamine (serotonin) receptor 2B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: 5-HT2Bprovided by FlyBase
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 2Bprovided by FlyBase
Primary source: FLYBASE:FBgn0261929
Locus tag: Dmel_CG42796
See related: AllianceGenome:FB:FBgn0261929
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5-HT-2b; 5-HT[[2B]]; 5HT1b; 5HT2b; 5HT2B; anon-WO0170980.94; anon-WO0170980.95; anon-WO0170980.97; anon-WO0170980.98; CG42796; CG7994; CG8007; d5-HT2B; Dm5-ht2b; Dm5-HT2B; Dm5-HT[[2B]]; Dmel\CG42796
Old locus tag: Dmel_CG7994; Dmel_CG8007
Summary: Enables G protein-coupled serotonin receptor activity. Involved in serotonin receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in adult head and hemocyte. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A); HTR2B (5-hydroxytryptamine receptor 2B); and HTR2C (5-hydroxytryptamine receptor 2C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8578205..8629996)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4403927..4455718)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain