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Zif Zinc-finger protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40795, updated on 5-May-2024

Summary

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Official Symbol
Zifprovided by FlyBase
Official Full Name
Zinc-finger proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037446
Locus tag
Dmel_CG10267
See related
AllianceGenome:FB:FBgn0037446
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.391; CC32; CG10267; Dmel\CG10267; zif; ZIF
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in establishment or maintenance of neuroblast polarity; larval lymph gland hemopoiesis; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic brain; embryonic/larval midgut; embryonic/larval nervous system; gonad; and somatic precursor cell. Orthologous to human ZNF233 (zinc finger protein 233) and ZNF527 (zinc finger protein 527). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
83E8-83E8; 3-47.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6457088..6458822)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2282810..2284544)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44017 Neighboring gene grappa Neighboring gene mir-9375 stem loop Neighboring gene uncharacterized protein Neighboring gene neurochondrin Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The regulation of cell size and branch complexity in the terminal cells of the Drosophila tracheal system. Burguete AS, et al. Dev Biol, 2019 Jul 1. PMID 30735663, Free PMC Article
  2. Transcriptional and epigenetic signatures of zygotic genome activation during early Drosophila embryogenesis. Darbo E, et al. BMC Genomics, 2013 Apr 5. PMID 23560912, Free PMC Article
  3. Global analysis of target genes of 21 members of the ZAD transcription factor family in Drosophila melanogaster. Krystel J, et al. Gene, 2013 Jan 10. PMID 23085320, Free PMC Article
  4. Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal. Chang KC, et al. Dev Cell, 2010 Nov 16. PMID 21074726
  5. Twenty-seven ZAD-ZNF genes of Drosophila melanogaster are orthologous to the embryo polarity determining mosquito gene cucoid. Li M, et al. PLoS One, 2023. PMID 36595500, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Zif is a transcription factor that directly represses aPKC transcription.
    Title: Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in establishment or maintenance of neuroblast polarity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in larval lymph gland hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc-finger protein
Names
CG10267-PA
CG10267-PB
CG10267-PC
Zif-PA
Zif-PB
Zif-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    6457088..6458822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275390.1 → NP_001262319.1  Zinc-finger protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262319.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VI24
    Conserved Domains (4) summary
    COG5048
    Location:250 → 369
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07776
    Location:9 → 87
    zf-AD; Zinc-finger associated domain (zf-AD)
    pfam13465
    Location:266 → 288
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001202259.2 → NP_001189188.1  Zinc-finger protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189188.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VI24
    Conserved Domains (4) summary
    COG5048
    Location:250 → 369
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07776
    Location:9 → 87
    zf-AD; Zinc-finger associated domain (zf-AD)
    pfam13465
    Location:266 → 288
    zf-H2C2_2; Zinc-finger double domain

  3. NM_141400.4 → NP_649657.1  Zinc-finger protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649657.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VI24
    Related
    FBpp0081225
    Conserved Domains (4) summary
    COG5048
    Location:250 → 369
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253 → 273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam07776
    Location:9 → 87
    zf-AD; Zinc-finger associated domain (zf-AD)
    pfam13465
    Location:266 → 288
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VI24 Q9VI24

Gene LinkOut

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