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Cerk Ceramide kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40640, updated on 18-Sep-2024

Summary

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Official Symbol
Cerkprovided by FlyBase
Official Full Name
Ceramide kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037315
Locus tag
Dmel_CG16708
See related
AllianceGenome:FB:FBgn0037315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CerK; CG16708; dcerk; dCerk; Dcerk; DCERK; Dmel\CG16708
Summary
Enables ceramide kinase activity. Involved in ceramide metabolic process; phototransduction; and pole cell migration. Located in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval posterior spiracle; extended germ band embryo; and gut section. Orthologous to human CERK (ceramide kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
82F11-83A1; 3-47.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5358873..5368306, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1184595..1194028, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Proteasome beta7 subunit Neighboring gene long non-coding RNA:CR44103 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CDase is a pan-ceramidase in Drosophila. Yuan C, et al. Mol Biol Cell, 2011 Jan 1. PMID 21148295, Free PMC Article
  2. Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction. Dasgupta U, et al. Proc Natl Acad Sci U S A, 2009 Nov 24. PMID 19892737, Free PMC Article
  3. A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons. Ghosh A, et al. PLoS Genet, 2013. PMID 24348263, Free PMC Article
  4. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. McElwain MA, et al. PLoS One, 2011. PMID 22069480, Free PMC Article
  5. Differential efficacy of genetically swapping GAL4. Chen YJ, et al. J Neurogenet, 2019 Mar-Jun. PMID 30939963

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c5366990-5365369 mobile_element_type = transposon:HB{}1219

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ceramide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ceramide kinase
Names
CG16708-PA
CG16708-PB
Cerk-PA
Cerk-PB
NP_649530.2
NP_730923.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5358873..5368306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169050.2 → NP_730923.1  ceramide kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730923.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNA6
    Related
    FBpp0078446
    Conserved Domains (1) summary
    PLN02204
    Location:157 → 658
    PLN02204; diacylglycerol kinase

  2. NM_141273.3 → NP_649530.2  ceramide kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649530.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNA6
    Related
    FBpp0078447
    Conserved Domains (1) summary
    PLN02204
    Location:157 → 658
    PLN02204; diacylglycerol kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95S15 Q95S15
Q9VNA6 Q9VNA6

Gene LinkOut

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