EDNRB endothelin receptor type B [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: EDNRBprovided by VGNC
Official Full Name: endothelin receptor type Bprovided by VGNC
Primary source: VGNC:VGNC:40203
See related: Ensembl:ENSCAFG00845027774
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: ET-B; ET-BR
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	22	NC_051826.1 (31733123..31756544, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	22	NC_006604.4 (31277699..31297545, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	22	NC_049243.1 (31507052..31526893, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	22	NC_049282.1 (31396562..31416398, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	22	NC_049763.1 (31434803..31454631, complement)

Chromosome 22 - NC_051826.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that reduced cardiac contractile and pulmonary vasoconstrictor responses via the ETB receptor are attenuated and that responses mediated by the ETA receptor are more prominent in the context of heart failure.
Title: The functional shift of endothelin receptor subtypes in dogs with heart failure produced by rapid ventricular pacing.

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General gene information

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Markers

EDNRB (e-PCR)
- UniSTS:263019

EDNRB-2 (e-PCR)
- UniSTS:253890

EDNRB (e-PCR)
- UniSTS:505343

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables endothelin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: endothelin receptor type B

Names: endothelin B receptor; endothelin receptor B; endothelin receptor non-selective type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010943.2 → NP_001010943.2 endothelin receptor type B precursor

Status: VALIDATED

Source sequence(s)

AB183285, AF276427

UniProtKB/TrEMBL

Q9MYZ5

Conserved Domains (2) summary

pfam00001
Location:119 → 385

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:113 → 400

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051826.1 Reference ROS_Cfam_1.0

Range

31733123..31756544 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038430763.1 → XP_038286691.1 endothelin receptor type B isoform X1

UniProtKB/TrEMBL

A0A8C0R7H2, A0A8C0RCP5, Q9MYZ5

Related

ENSCAFP00845038478.1, ENSCAFT00845049040.1

Conserved Domains (2) summary

PHA03247
Location:23 → 90

PHA03247; large tegument protein UL36; Provisional

cd15976
Location:103 → 398

7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_038430764.1 → XP_038286692.1 endothelin receptor type B isoform X2

UniProtKB/TrEMBL

A0A8I3QEN5, A0A8P0PLZ6

Conserved Domains (2) summary

PHA03247
Location:23 → 90

PHA03247; large tegument protein UL36; Provisional

cd15976
Location:103 → 398

7tmA_ET-BR; endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors