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SCNN1A sodium channel epithelial 1 subunit alpha [ Canis lupus familiaris (dog) ]

Gene ID: 403650, updated on 17-Aug-2024

Summary

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Official Symbol
SCNN1Aprovided by VGNC
Official Full Name
sodium channel epithelial 1 subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:45925
See related
Ensembl:ENSCAFG00845029331
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 27
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (38968240..38994329)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (7976259..8002278, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (7455013..7481038, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (38840880..38866869)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (38882321..38908328)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene TAP binding protein like Neighboring gene CD27 molecule Neighboring gene lymphotoxin beta receptor Neighboring gene TNF receptor superfamily member 1A Neighboring gene pleckstrin homology and RhoGEF domain containing G6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct pools of epithelial sodium channels are expressed at the plasma membrane. Hughey RP, et al. J Biol Chem, 2004 Nov 19. PMID 15466477
  2. Epithelial sodium channel exit from the endoplasmic reticulum is regulated by a signal within the carboxyl cytoplasmic domain of the alpha subunit. Mueller GM, et al. J Biol Chem, 2007 Nov 16. PMID 17855354
  3. The alpha-subunit of the epithelial sodium channel is an aldosterone-induced transcript in mammalian collecting ducts, and this transcriptional response is mediated via distinct cis-elements in the 5'-flanking region of the gene. Mick VE, et al. Mol Endocrinol, 2001 Apr. PMID 11266509
  4. ENaC subunit-subunit interactions and inhibition by syntaxin 1A. Berdiev BK, et al. Am J Physiol Renal Physiol, 2004 Jun. PMID 14996668
  5. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit. Passero CJ, et al. J Biol Chem, 2008 Dec 26. PMID 18981180, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit
    Title: Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.
  2. ER exit of ENaC is regulated by a signal within the alpha subunit carboxyl cytoplasmic tail
    Title: Epithelial sodium channel exit from the endoplasmic reticulum is regulated by a signal within the carboxyl cytoplasmic domain of the alpha subunit.
  3. Our findings provide evidence for a direct physical interaction between ENaC and syntaxin 1A and suggest involvement of ENaC's cytoplasmic domains in functional modulation of ENaC activity by syntaxin 1A
    Title: ENaC subunit-subunit interactions and inhibition by syntaxin 1A.
  4. epithelial sodium channels are expressed at the plasma membrane
    Title: Distinct pools of epithelial sodium channels are expressed at the plasma membrane.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
amiloride-sensitive sodium channel subunit alpha
Names
alpha ENaC
epithelial sodium channel alpha subunit
sodium channel epithelial 1 alpha subunit
sodium channel, non-voltage-gated 1 alpha subunit
sodium channel, nonvoltage-gated 1 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    38968240..38994329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038439218.1 → XP_038295146.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8I3Q679
    Conserved Domains (1) summary
    TIGR00859
    Location:34 → 627
    ENaC; sodium channel transporter

  2. XM_038439219.1 → XP_038295147.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8I3Q679
    Conserved Domains (1) summary
    TIGR00859
    Location:34 → 627
    ENaC; sodium channel transporter

  3. XM_038439217.1 → XP_038295145.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8I3Q679
    Conserved Domains (1) summary
    TIGR00859
    Location:34 → 627
    ENaC; sodium channel transporter

  4. XM_038439216.1 → XP_038295144.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8I3Q679
    Related
    ENSCAFP00845040758.1, ENSCAFT00845051947.1
    Conserved Domains (1) summary
    TIGR00859
    Location:34 → 627
    ENaC; sodium channel transporter

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    38840880..38866869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038513879.1 → XP_038369807.1  amiloride-sensitive sodium channel subunit alpha

  2. XM_038513881.1 → XP_038369809.1  amiloride-sensitive sodium channel subunit alpha

  3. XM_038513878.1 → XP_038369806.1  amiloride-sensitive sodium channel subunit alpha

  4. XM_038513877.1 → XP_038369805.1  amiloride-sensitive sodium channel subunit alpha

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    38882321..38908328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038641725.1 → XP_038497653.1  amiloride-sensitive sodium channel subunit alpha

  2. XM_038641726.1 → XP_038497654.1  amiloride-sensitive sodium channel subunit alpha

  3. XM_038641724.1 → XP_038497652.1  amiloride-sensitive sodium channel subunit alpha

  4. XM_038641723.1 → XP_038497651.1  amiloride-sensitive sodium channel subunit alpha

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    7455013..7481038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038576561.1 → XP_038432489.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8C0PLX6, A0A8P0TEQ4

  2. XM_038576562.1 → XP_038432490.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8C0PLX6, A0A8P0TEQ4

  3. XM_038576560.1 → XP_038432488.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8C0PLX6, A0A8P0TEQ4

  4. XM_038576559.1 → XP_038432487.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8C0PLX6, A0A8P0TEQ4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    7976259..8002278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014108588.3 → XP_013964063.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8C0PLX6, A0A8P0TEQ4
    Conserved Domains (1) summary
    TIGR00859
    Location:34 → 627
    ENaC; sodium channel transporter

  2. XM_005637255.4 → XP_005637312.1  amiloride-sensitive sodium channel subunit alpha

    See identical proteins and their annotated locations for XP_005637312.1

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8C0PLX6, A0A8P0TEQ4
    Conserved Domains (1) summary
    TIGR00859
    Location:34 → 627
    ENaC; sodium channel transporter

  3. XM_022410921.2 → XP_022266629.1  amiloride-sensitive sodium channel subunit alpha

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8C0PLX6, A0A8P0TEQ4
    Conserved Domains (1) summary
    TIGR00859
    Location:34 → 627
    ENaC; sodium channel transporter

  4. XM_005637254.4 → XP_005637311.1  amiloride-sensitive sodium channel subunit alpha

    See identical proteins and their annotated locations for XP_005637311.1

    UniProtKB/TrEMBL
    A0A8C0KNS5, A0A8C0PLX6, A0A8P0TEQ4
    Conserved Domains (1) summary
    TIGR00859
    Location:34 → 627
    ENaC; sodium channel transporter
Nucleotide Protein
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