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Cyp312a1 Cytochrome P450 312a1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40005, updated on 18-Sep-2024

Summary

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Official Symbol
Cyp312a1provided by FlyBase
Official Full Name
Cytochrome P450 312a1provided by FlyBase
Primary source
FLYBASE:FBgn0036778
Locus tag
Dmel_CG5137
See related
AllianceGenome:FB:FBgn0036778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
312a1; CG5137; Dmel\CG5137; P450 IV
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; gonad; and organism. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
75B11-75B11; 3-45 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18128940..18132689, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18122040..18125789, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44669 Neighboring gene geko

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Geko, a novel gene involved in olfaction in Drosophila melanogaster. Shiraiwa T, et al. J Neurogenet, 2000 Sep. PMID 10992166
  2. Male specific expression of a cytochrome P450 (Cyp312a1) in Drosophila melanogaster. Kasai S, et al. Biochem Biophys Res Commun, 2003 Jan 24. PMID 12559957
  3. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
  4. The Drosophila Post-mating Response: Gene Expression and Behavioral Changes Reveal Perdurance and Variation in Cross-Tissue Interactions. Newell NR, et al. G3 (Bethesda), 2020 Mar 5. PMID 31907222, Free PMC Article
  5. The Sf1-related nuclear hormone receptor Hr39 regulates Drosophila female reproductive tract development and function. Allen AK, et al. Development, 2008 Jan. PMID 18077584

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 312a1
Names
CG5137-PA
CG5137-PB
Cyp312a1-PA
Cyp312a1-PB
cytochrome P450
NP_001262008.1
NP_649030.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18128940..18132689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275079.1 → NP_001262008.1  cytochrome P450 312a1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262008.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1ECB7, Q9VVN6
    UniProtKB/TrEMBL
    M9PI92
    Conserved Domains (1) summary
    pfam00067
    Location:35 → 505
    p450; Cytochrome P450

  2. NM_140773.3 → NP_649030.1  cytochrome P450 312a1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649030.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1ECB7, Q9VVN6
    UniProtKB/TrEMBL
    M9PI92
    Related
    FBpp0074901
    Conserved Domains (1) summary
    pfam00067
    Location:35 → 505
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI92 M9PI92
Q9VVN6.1 Q9VVN6

Gene LinkOut

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