ptk7.L protein tyrosine kinase 7 (inactive) L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ptk7.L
Official Full Name: protein tyrosine kinase 7 (inactive) L homeolog
Primary source: Xenbase:XB-GENE-5846983
Locus tag: XELAEV_18026427mg
See related: EnsemblRapid:ENSXLAG00005027828
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: E30; klg; cck4; ptk7; cck-4; ptk-7
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Genomic context

Location:: chromosome: 5L

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (24632000..24663863)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (23824737..23856600)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows in vivo proof that these smaller PTK7 proteolytic fragments can recapitulate full-length PTK7 protein activity in diverse systems, such as vertebrate nervous system development.
Title: PTK7 proteolytic fragment proteins function during early Xenopus development.
This study reveals novel molecular mechanisms of action of PTK7 in non-canonical WNT/PCP signaling that may promote cell and tissue movements.
Title: The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway.
PTK7 and LRP6 proteins physically interact, suggesting that PTK7 stabilization of LRP6 protein reciprocally regulates both canonical and noncanonical Wnt activities in the embryo.
Title: PTK7 modulates Wnt signaling activity via LRP6.
Xenopus Protein Tyrosine Kinase 7 is required for the formation of Spemann's organizer and for Siamois promoter activation
Title: Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling.
PlexinA1 and PTK7 interaction is evolutionary conserved and may be relevant for a broad range of morphogenetic events including the migration of neural crest cells in Xenopus laevis.
Title: PlexinA1 interacts with PTK7 and is required for neural crest migration.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables axon guidance receptor activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein tyrosine kinase 7 (inactive) L homeolog

Names: PTK7 protein tyrosine kinase 7

NP_001083315.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089846.1 → NP_001083315.1 protein tyrosine kinase 7 (inactive) L homeolog precursor

See identical proteins and their annotated locations for NP_001083315.1

Status: PROVISIONAL

Source sequence(s)

BC060500

UniProtKB/TrEMBL

A0A974CTU3, Q6PA07

Related

ENSXLAP00005083304.1, ENSXLAT00005084942.1

Conserved Domains (7) summary

cd05046
Location:763 → 1034

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd00096
Location:231 → 285

Ig; Immunoglobulin domain

smart00408
Location:504 → 559

IGc2; Immunoglobulin C-2 Type

smart00221
Location:774 → 1032

STYKc; Protein kinase; unclassified specificity

smart00410
Location:581 → 663

IG_like; Immunoglobulin like

pfam07679
Location:486 → 571

I-set; Immunoglobulin I-set domain

cl11960
Location:135 → 211

Ig; Immunoglobulin domain